Laboratory Study
Eye (2008) 22, 969–974; doi:10.1038/sj.eye.6703062; published online 14 December 2007
Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients
N Angayarkanni1, S Barathi1, T Seethalakshmi1, R Punitham1, R Sivaramakrishna1, G Suganeswari2 and S Tarun2
- 1Biochemistry Research Department, Sankara Nethralaya, Vision Research Foundation, Chennai, India
- 2Vitreo Retinal Department, Sankara Nethralaya, Vision Research Foundation, Chennai, India
Correspondence: N Angayarkanni, Biochemistry Research Department, Sankara Nethralaya, Vision Research Foundation, 18, College Road, Chennai, Tamil Nadu 600 006, India. Tel: +91 44 28271616; Fax: +91 44 28254180. E-mail: drak@snmail.org
Received 15 June 2007; Accepted 10 November 2007; Published online 14 December 2007.
Abstract
Aim
To estimate the arylesterase activity of serum paraoxonase-1 (PON1-ARE), which is reported to have an antioxidant and antiatherogenic potential and to correlate with plasma homocysteine (Hcys) and plasma TBARS in young adult central retinal venous occlusion (CRVO) patients.
Methods
A case–control prospective study carried out in 10 CRVO patients (mean age 27
5 years; 7 males, 3 females) and 20 healthy controls (mean age 295 years; 15 males, 5 females).
Results
The CRVO patients showed a significantly lowered serum PON1-ARE activity (P=0.009) along with a significant increase in the levels of plasma Hcys (P=0.018) when compared to the control subjects. There was a negative correlation between serum PON1-ARE and plasma Hcys levels (P=0.058) as well as between PON1-ARE and plasma TBARS levels (P=0.001) in the CRVO patients.
Conclusion
This is the first report of lowered serum PON1-ARE level as a risk factor for CRVO (OR= 1.108, CI=0.914, 1.314; P=0.296), which is found to correlate with oxidative stress.
Keywords:
CRVO, paraoxonase, homocysteine, oxidative stress
