Penetration of topically applied levofloxacin into eyes with thin-wall filtering bleb after trabeculectomy

doi:doi:10.1038/sj.eye.6702712

Eye (2008) 22, 666–670; doi:10.1038/sj.eye.6702712; published online 2 March 2007

Penetration of topically applied levofloxacin into eyes with thin-wall filtering bleb after trabeculectomy

This work was presented at The World Glaucoma Congress, Vienna, Austria, 6–9 July 2005

L Y Qiao^1,2, N L Wang², Y B Liang², S Q Zhu², X H Wan² and P-Y Lee²

¹Guangzhou Zhongshan Ophthalmic Center, Sun Yatsen University, Guangzhou, China
²Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

Correspondence: NL Wang, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang street, Dongcheng District, Beijing 100730, China. Tel: +86 10 5826 9919; Fax: +86 10 5826 9920; E-mail: wningli@ trhos.com

Received 15 June 2006; Accepted 30 November 2006; Published online 2 March 2007.

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Abstract

Purpose

To investigate the comparative penetration of 0.3% levofloxacin eye drops into the aqueous humour between cataract patients with or without (control) thin-wall filtering blebs.

Methods

One drop of 0.3% levofloxacin was administered to the eyes at 30-min intervals for 3.5 h before phacoemulcification for both groups. Aqueous humour samples (0.1–0.2 ml) were aspirated during surgery. The concentration of levofloxacin in the aqueous humour was determined by high-performance liquid chromatography. The Student's t-test, Pearson correlation, and ² test were used to compare the data of the two groups. A P<0.05 was required for results to be considered statistically significant.

Results

The levofloxacin concentration in the aqueous humour was significantly increased (P<0.0001) in the bleb (mean+SD: 3.7 plusminus 2.3 g/ml) vscontrol group (0.40.2 g/ml). Intraocular pressure and the bleb area were not correlated with levofloxacin concentration.