Clinical Study
Eye (2008) 22, 406–413; doi:10.1038/sj.eye.6702654; published online 16 February 2007
Stratus-OCT imaging in early glaucomatous and in ocular hypertensive patients with and without frequency-doubling technology abnormalities
P Brusini1, M Zeppieri1,2,3, C Tosoni1, L Parisi1, M Felletti1 and M L Salvetat1
- 1Department of Ophthalmology, S. Maria della Misericordia Hospital, Udine, Italy
- 2Department of Ophthalmology, University of Udine, Udine, Italy
- 3Discoveries in Sight, Devers Eye Institute, Portland, OR, USA
Correspondence: P Brusini, Department of Ophthalmology, S. Maria della Misericordia Hospital, Piazzale S. Maria della Misericordia 15, Udine 33100, Italy. Tel: +432 552747; Fax: +432 552741; E-mail: brusini@libero.it or prim.oculistica@aoud.sanita.fvg.it
Received 14 March 2006; Revised 30 September 2006; Accepted 30 September 2006; Published online 16 February 2007.
Abstract
Aim
To compare Stratus-OCT measurements in controls, ocular hypertensive (OHT) patients with (FDT+) and without (FDT-) frequency-doubling technology (FDT) abnormalities, and in patients affected with early primary open-angle glaucoma (POAG).
Methods
Thirty-two controls, 78 OHT patients (38 FDT- and 40 FDT+), and 45 early POAG patients (six FDT- and 39 FDT+) underwent the following tests within 3 months: standard automated perimetry (SAP) HFA 30–2; FDT N-30-F; and, Stratus-OCT imaging with retinal nerve fibre layer (RNFL) and optic nerve head (ONH) scans. One eye per patient was considered. Differences among groups were evaluated using the Kruskal–Wallis, analysis of variance, and Duncan's tests.
Results
There were no significant differences in all Stratus-OCT parameters between POAG and OHT FDT+ patients. Statistically significant differences were found between the control group and both the POAG and OHT FDT+ groups for 15 of the 21 Stratus-OCT parameters. Control eyes compared to OHT FDT- showed significant differences in 13 of the 21 parameters. The comparison between the OHT FDT- group, and both the POAG and OHT FDT+ group resulted in 13 of the 21 parameters to be significantly different.
Conclusions
Stratus-OCT seems to show a higher ability in detecting significant differences between healthy, OHT, and early POAG eyes when compared to SAP and FDT. This suggests that the Stratus-OCT could show structural abnormalities before SAP or FDT visual field defects appear in patients at risk of developing glaucoma, which may be beneficial in making therapeutic decisions, especially in OHT patients.
Keywords:
primary open-angle glaucoma, ocular hypertension, standard automated perimetry, frequency-doubling technology, optical coherence tomography
