Clinical Study
Eye (2008) 22, 1488–1492; doi:10.1038/sj.eye.6702902; published online 8 June 2007
Higher-order wavefront aberration and letter-contrast sensitivity in keratoconus
C Okamoto1, F Okamoto1, T Samejima2, K Miyata2 and T Oshika1
- 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
- 2Meiwakai Miyata Eye Hospital, Miyazaki, Japan
Correspondence: T Oshika, Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan. Tel: +81 29 853 3148; Fax: +81 29 853 3148. E-mail: toshika@md.tsukuba.ac.jp
Received 11 April 2007; Accepted 15 May 2007; Published online 8 June 2007.
Abstract
Aims
To evaluate the relation between higher-order aberration of the eye and contrast sensitivity function in eyes with keratoconus.
Methods
In 22 eyes of 14 patients with keratoconus (age 30.5
8.4 years, meansSD) and 26 eyes of 13 normal controls (age 29.26.7 years), ocular higher-order wavefront aberration for a 6-mm pupil was measured with the Hartmann-Schack aberrometer (KR-9000 PW, Topcon). The root mean square (RMS) of third- and fourth-order Zernike coefficients was used to represent higher-order aberrations. The letter-contrast sensitivity was examined using the CSV-1000LV contrast chart (Vector Vision).
Results
In the keratoconus group, the letter-contrast sensitivity showed significant correlation with third-order (Spearman's correlation coefficient r=-0.736, P<0.001) and fourth-order aberrations (r=-0.464, P<0.05). There was borderline correlation between log MAR BSCVA and third-order (r=0.413, P=0.070) and fourth-order aberrations (r=0.394, P=0.086). In the normal group, the letter-contrast sensitivity had no significant correlation with third-order (r=-0.170, P=0.411) and fourth-order aberrations (r=-0.088, P=0.673), and log MAR best spectacle-corrected visual acuity (BSCVA) showed no correlation with third-order (r=0.063, P=0.762) and fourth-order aberrations (r=-0.282, P=0.165).
Conclusions
In eyes with keratoconus, there is significant correlation between contrast sensitivity and ocular higher-order wavefront aberrations.
Keywords:
keratoconus, wavefront aberration, higher-order aberration, contrast sensitivity, letter-contrast sensitivity
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