Clinical Study
Eye (2007) 21, 984–989; doi:10.1038/sj.eye.6702375; published online 19 May 2006
An evaluation of the darkroom prone provocative test in family members of primary angle closure glaucoma patients
R Sihota1, S Mohan1, T Dada1, V Gupta1, R M Pandey1 and D Ghate1
1Glaucoma Research Lab, Dr. Rajendra Prasad centre for ophthalmic sciences, All India Institute of Medical Sciences, New Delhi, India
Correspondence: T Dada, RP Center for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Tel: +91 11 265 89695; Fax: +91 11 265 88919; E-mail: tanujdada@hotmail.com
Received 19 October 2005; Revised 1 March 2006; Accepted 7 March 2006; Published online 19 May 2006.
Abstract
Purpose
To compare ocular biometric parameters with darkroom prone provocative test (DRPPT) in family members of primary angle closure glaucoma (PACG) patients.
Methods
One hundred and forty-nine family members of 46 PACG patients underwent ocular examination included slit lamp biomicroscopy, gonioscopy, fundus examination using +90 D lens, Goldmann applanation tonometry, darkroom prone provocative test, perimetry on Humphrey's field analyzer II and optic disc evaluation using HRT II. Ultrasonic ocular biometry and the DRPPT were then performed. IOP
8 mmHg rise from baseline with iridocorneal touch was considered as a positive test.
Results
Of the 149 family members examined, 55 (36.9%) were found to have PACG. Forty (72.7%) of these had subacute PACG and 15 (27.3%) were found to have chronic PACG. Thirty-nine (70.3%) of the affected members showed a positive DRPPT. Mean anterior chamber depth (ACD) was 2.03
0.3, 2.30.4, 2.70.3 mm (P=0.0001) and mean lens thickness was 4.410.39, 3.990.5, 3.930.4 mm (P=0.0001) in DRPPT positives, borderlines and negatives respectively. ROC curve (ACD) plotted showed cutoff value of 2.07 mm (sensitivity 88.57%) for screening.
Conclusion
Anterior chamber is shallowest, lens is thickest and axial length is shortest in affected and DRPPT positive, family members of PACG patients.
Keywords:
darkroom prone test, biometry, primary angle closure glaucoma
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