Clinical Study
Eye (2006) 20, 583–590. doi:10.1038/sj.eye.6701932; published online 3 June 2005
The clinical validity of the treatment satisfaction survey for intraocular pressure in ocular hypertensive and glaucoma patients
D G Day1, E D Sharpe2, M J Atkinson3, J A Stewart4 and W C Stewart4,5
- 1Atlanta Research Company, Atlanta, GA, USA
- 2Charleston Research Company, Charleston, SC, USA
- 3Pfizer, Inc., Worldwide Outcomes Research, San Diego, CA, USA
- 4Pharmaceutical Research Network, LLC, Charleston, SC, USA
- 5Carolina Eye Institute at the University of South Carolina School of Medicine, Columbia, SC, USA
Correspondence: WC Stewart, Pharmaceutical Research Network, LLC, 1 Southpark Circle, Suite 110, Charleston, SC 29407, USA. Tel: +1 843 762 6500; Fax: +1 843 762 7444; E-mail: info@prnorb.com
Received 16 December 2004; Accepted 12 April 2005; Published online 3 June 2005.
Abstract
Purpose
To provide initial validation of the Treatment Satisfaction Survey-Intraocular Pressure (TSS-IOP) quality-of-life survey that analyses specific issues related to side effects, patient satisfaction, and compliance.
Methods
A prospective, observational cohort of 250 consecutive patients with primary open-angle glaucoma or ocular hypertension was administered the TSS-IOP survey.
Results
Factors that correlated with patient satisfaction included perceived effectiveness of the medicine (F=7.47, P<0.001), ocular irritation (F=6.06, P<0.001), conjunctival hyperaemia (F=4.40, P<0.001), ease of use (F=8.52, P<0.001), and convenience of use (F=6.90, P<0.001). Patient compliance, acceptance of their illness, and knowledge of glaucoma were also related to perceived effectiveness of the medicine (P<0.001), ease of use (P<0.05) and convenience (P<0.001). Physician ratings of patient pressure control, side effects, and instillation problems also were significantly correlated to patient satisfaction (R=0.13–0.26, P=0.05–0.001). The physician ratings of patient compliance, however, were not significantly related to any dimension of patient satisfaction (P>0.05). Among monotherapy prostaglandin treatments, latanoprost demonstrated statistically greater satisfaction than bimatoprost or travoprost regarding conjunctival hyperaemia (P<0.05) and eye irritation (P<0.01).
Conclusions
This study provides initial evidence that patient satisfaction may be related to compliance, perceived effectiveness of treatment, adverse side effects, ease and convenience of use, acceptance of illness, and knowledge of glaucoma.
Keywords:
glaucoma, satisfaction, compliance, treatment effectiveness, convenience
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