Clinical Study
Eye (2006) 20, 579–582. doi:10.1038/sj.eye.6701931; published online 27 May 2005
Effect of hyaluronidase on ocular motility and eyelid function in sub-Tenon's anaesthesia: randomised controlled trial
Presented at the Meeting of UKISCRS, Countess of Chester Hospital, Chester, UK 10 September 2004.
S Aslam1, S J Sarker2, M Tran-Dang1, L Yuen1, M Niskopoulou1, D Thomas1 and T Poole1
- 1Frimley Park Hospital, Camberley, Surrey, UK
- 2Medical and Pharmaceutical Statistics Research Unit, School of Applied Statistics, The University of Reading, Reading, UK
Correspondence: S Aslam, Frimley Park Hospital, Portsmouth Road, Camberley, Surrey GU16 7UJ, UK. Tel: 079 1732 5562; Fax: 020 8961 0012; E-mail: sheraslam2@yahoo.com
Received 13 February 2005; Revised 23 March 2005; Accepted 23 March 2005; Published online 27 May 2005.
Abstract
Purpose
To assess the effect of hyaluronidase on eye and eyelid movements when used as an adjunct in sub-Tenon's anaesthesia.
Methods
A total of 60 patients who had sub-Tenon's anaesthesia prior to phacoemulsification surgery were divided into two equal groups in a double-masked randomised controlled fashion. Of these, Group A had 4 ml lignocaine 2%, while Group B had 4 ml lignocaine 2% with the addition of sodium hyaluronidase 75 IU/ml. Ocular motility, levator, and orbicularis oculi function were measured in all patients at 5 and 8 min. Levator function was scored from 0 (no function) to 3 (complete function) while orbicularis function was scored from 0 to 2. The score for ocular motility was the sum in four positions of gaze, each position scoring from 0 to 2. Results were compared using a nonparametric test.
Results
Group B achieved significantly better ocular and lid akinesia than Group A both at 5 and 8 min with P<0.01. The median scores for levator function at 5 and 8 min were 2 for Group A and 0 for Group B. For orbicularis function, the median scores at both time intervals were 2 for Group A and 1 for Group B. For ocular motility, the median score for Group A at 5 min was 3 and at 8 min was 2.5; for Group B at 5 min was 0.5 and at 8 min was 0.
Conclusions
The addition of hyaluronidase in sub-Tenon's anaesthesia has a significant effect in improving ocular and lid (levator and orbicularis) akinesia.
Keywords:
sub-Tenon, hyaluronidase, motility
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