Clinical Study
Eye (2005) 19, 292–297. doi:10.1038/sj.eye.6701466 Published online 16 July 2004
Relationship of Gender, Body Mass Index, and Axial Length with Central Retinal Thickness Using Optical Coherence Tomography
This study is part of the eye screening project financially supported by the Tung Wah Group Research Fund The authors have no proprietary interest in the devices used
A C M Wong1, C W N Chan1 and S P Hui1
1Lo Ka Chow Memorial Ophthalmic Centre, Tung Wah Eastern Hospital, Causeway Bay, Hong Kong
Correspondence: ACM Wong, Lo Ka Chow Memorial Ophthalmic Centre, Tung Wah Eastern Hospital, Causeway Bay, Hong Kong. Tel: +852 2162 6901; Fax: +852 2882 9909; E-mail: albertcmw@sinaman.com
Received 3 September 2003; Accepted 6 January 2004; Published online 16 July 2004.
Abstract
Background
Optical coherence tomography (OCT) acquires cross-sectional retinal images with high resolution using low-coherence interferometry. Few studies have studied the effect of demographic data and ocular parameters that may affect central retinal thickness. In this study, these factors were used as parameters to analyse if any significant relationship exists with central retinal thickness.
Methods
Volunteers with a best-corrected visual acuity of 6/12 or better and no evidence of ocular abnormalities or interventions were recruited from October 2001 to March 2003. Body mass index (BMI), autorefraction, and keratometry recordings were measured, followed by applanation tonometry and A-scan ultrasonography. The central retinal thickness of the right eye was analysed using a scan length of 3 cm. Another 25 eyes were selected for interobserver reproducibility.
Results
In all, 117 normal subjects (60 male and 57 female subjects) were recruited. The mean thickness of the central retina with a diameter of 1 mm was 203
23 
m for male and 18920 m for female subjects. Age, intraocular pressure, and keratometric readings were not significantly correlated with central retinal thickness. Using multiple regression, gender, BMI, axial length, and signal-to-noise ratio (P<0.05) were significantly associated with the central retinal thickness. The intraclass correlation coefficient was 0.98 for interobserver reproducibility.
Conclusion
OCT has a high interobserver reproducibility. The male gender, larger BMI, and longer axial length are associated with a significantly thicker central retina and these parameters should be considered for assessing retinal thickening and baseline comparisons in future studies.
Keywords:
optical coherence tomography, axial length, gender, body mass index, Chinese
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