Clinical Study
Eye (2005) 19, 1297–1300. doi:10.1038/sj.eye.6701776; published online 14 January 2005
Cerebral haemodynamics in patients with pseudoexfoliation glaucoma
The authors have no commercial or proprietary interest in any of the equipment and medications mentioned in this study.
This study in part was presented as a poster in the 24th National Radiology Congress 8–11 October 2003, Ankara, Turkey.
nal- 1Department of Ophthalmology, University of Kirikkale, 71100 Kirikkale, Turkey
- 2Department of Radiology, University of Kirikkale, 71100 Kirikkale, Turkey
Correspondence: C Akarsu, Cagdas Sokak 37/13, TR 06130, Aydinlikevler, Ankara, Turkey. Tel: +90 318 225 2820; Fax: +90 318 225 2819; E-mail: cengizakarsu@hotmail.com
Received 30 June 2004; Accepted 20 October 2004; Published online 14 January 2005.
Abstract
Purpose
To evaluate the cerebral haemodynamics in patients with pseudoexfoliation glaucoma.
Methods
A total of 19 consecutive patients with pseudoexfoliation glaucoma and 19 age- and sex-matched healthy volunteers were recruited in a prospective comparative study. The affected eye in patients with unilateral glaucoma and the eye with more advanced lesions in patients with bilateral glaucoma were included in the study, and the ipsilateral middle cerebral arteries (MCA) were evaluated. While in the controls, the study eye and the ipsilateral MCA were chosen randomly. Measurements included systemic arterial pressure, heart rate, intraocular pressure (IOP), and transcranial colour Doppler parameters, including peak systolic velocity (PSV), end-diastolic velocity (EDV), time-averaged maximum velocity (TAMAX), resistivity index (RI), and pulsatility index (PI).
Results
The mean PSV, EDV, and TAMAX were significantly lower in the patients with pseudoexfoliation glaucoma than in healthy controls (P<0.001, <0.001 and <0.001, respectively). Additionally, patients with pseudoexfoliation glaucoma had significantly higher PI and RI than healthy controls (P=0.001 and 0.04, respectively). Systolic and diastolic blood pressures (P=0.19 and 0.91, respectively) and heart rate (P=0.06) were not different between the groups. The mean IOP were significantly higher in the glaucoma patients compared with the controls (P<0.001).
Conclusion
This study suggests that pseudoexfoliation glaucoma is associated with a reduction in the blood flow velocity and elevation in the resistance of the MCA.
Keywords:
pseudoexfoliation glaucoma, cerebral haemodynamics, transcranial colour Doppler
