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EMBO reports AOP
doi:10.1038/embor.2008.70
Published online: 2 May 2008
A transcription cofactor required for the heat-shock response
Danmei Xu, L Panagiotis Zalmas & Nicholas B La Thangue
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Laboratory of Cancer Biology, Medical Sciences Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
To whom correspondence should be addressed
Nicholas B La Thangue Tel: +44 (0)1865 220342; Fax: +44 (0)1865 220524; E-mail: nick.lathangue@ndcls.ox.ac.uk
Received 8 August 2007; Accepted 31 March 2008; Published online 2 May 2008.
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Abstract
The Stress-responsive activator of p300 (Strap) is a transcription cofactor that has an important role in the control of DNA damage response through its ability to regulate p53 activity. Here, we report that Strap is inducible by heat shock and stimulates the transcription of heat-shock genes. A chromatin-associated complex involving heat-shock factor 1 (HSF1), Strap and the p300 coactivator assembles on the heat-shock protein 70 (hsp70) promoter, and Strap augments HSF1 binding and chromatin acetylation in Hsp genes, most probably through the p300 histone acetyltransferase. Cells depleted of Strap do not survive under heat-shock conditions. These results indicate that Strap is an essential cofactor that acts at the level of chromatin control to regulate heat-shock-responsive transcription.
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