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EMBO reports 9, 4, 330–336 (2008)
doi:10.1038/embor.2008.38
The role of kinases in the Hedgehog signalling pathway
Reid A Aikin*, Katie L Ayers* & Pascal P Thérond
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Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre de Biochimie, Université de Nice, Parc Valrose, 06108 Nice Cedex 02, France
To whom correspondence should be addressed
Pascal P Thérond Tel: +33 4 92 07 6446; Fax: +33 4 92 07 6405;
therond@unice.fr
* These authors contributed equally to this work
Received 9 January 2008; Accepted 21 February 2008.
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Abstract
The Hedgehog (Hh) signalling pathway has a crucial role in several developmental processes and is aberrantly activated in a variety of cancers. In Drosophila, many of the canonical Hh pathway components are phosphorylated, yet the precise role of these phosphorylation events in the regulation of Hh signal transduction is unclear. Furthermore, the Hh pathway receives input from several kinases that have well-described roles in other cellular functions, some of which have both positive and negative effects on Hh signalling. Several recent studies have characterized the role of specific phosphorylation events in the Hh pathway, and have begun to shed light on how phosphorylation of Hh signalling components affects their subcellular location, stability and activity to mediate the transcriptional response to the Hh gradient.
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