|
 |
|
|
|
EMBO reports 9, 3, 280–286 (2008)
doi:10.1038/embor.2008.10
AOP Published online: 15 February 2008
Ribosomal proteins are targets for the NEDD8 pathway
Dimitris P Xirodimas1, Anders Sundqvist1, Akihiro Nakamura2, Linnan Shen1, Catherine Botting3 & Ronald T Hay1
|
|
|
|
1 Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
2 Institute for Advanced Biosciences, Keio University, 403-1 Daihouji, Tsuruoka City, Yamagata 997-0017, Japan
3 Centre for Biomolecular Sciences, University of St Andrews, The North Haugh, St Andrews KY16 9ST, Scotland, UK
To whom correspondence should be addressed
Dimitris P Xirodimas Tel: +44 (0)1382 386303; Fax: +44 (0)1382 386375; E-mail: d.xirodimas@dundee.ac.uk
Received 27 July 2007; Accepted 14 January 2008; Published online 15 February 2008.
|
|
|
|
Abstract
Identification of the molecular targets for post-translational modifications is an important step for explaining the regulated pathways. The ubiquitin-like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization.
|
 |
|
Top of page MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated | |
|
top  |
|
|
|
