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EMBO reports 8, 9, 846–850 (2007)
doi:10.1038/sj.embor.7401044
AOP Published online: 3 August 2007
Messenger RNA conformations in the ribosomal E site revealed by X-ray crystallography
Lasse Jenner, Bernard Rees, Marat Yusupov & Gulnara Yusupova
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Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1, rue Laurent Fries, Illkirch 67404, France
To whom correspondence should be addressed
Gulnara Yusupova Tel: +33 3 88 65 35 45; Fax: +33 3 88 65 32 76; E-mail: gula@igbmc.u-strasbg.fr
Received 2 May 2007; Accepted 3 July 2007; Published online 3 August 2007.
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Abstract
A comparison of messenger RNA in X-ray crystal structures of 70S ribosomal complexes in the initiation, post-initiation and elongation states of translation shows distinct conformational differences in the exit (E) codon. Here, we present structural evidence indicating that, after the initiation event, the E codon nucleotides relax and form a classical A-helical conformation. This conformation is similar to that of the P and A codons, and is favourable for establishing Watson–Crick interactions with the anticodon of E-site transfer RNA.
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