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EMBO reports 8, 7, 644–650 (2007)
doi:10.1038/sj.embor.7401004
A concentric circle model of multivesicular body cargo sorting
Daniel P Nickerson, Matthew R G Russell & Greg Odorizzi
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Department of Molecular, Cellular, and Developmental Biology, University of Colorado, 347 UCB, Boulder, Colorado 80309-0347, USA
To whom correspondence should be addressed
Greg Odorizzi Tel: +1 303 735 0179; Fax: +1 303 492 7744;
odorizzi@colorado.edu
Received 5 December 2006; Accepted 7 May 2007.
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Abstract
Targeting of ubiquitylated transmembrane proteins into luminal vesicles of endosomal multivesicular bodies (MVBs) depends on their recognition by endosomal sorting complexes required for transport (ESCRTs), which are also required for MVB vesicle formation. The model originally proposed for how ESCRTs function succinctly summarizes much of the protein–protein interaction and genetic data but oversimplifies the coordination of cargo recognition and cannot explain why ESCRTs are required for the budding of MVB vesicles. Recent structural and functional studies of ESCRT complexes suggest an alternative model that might direct the next series of breakthroughs in understanding protein sorting through the MVB pathway.
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