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EMBO reports 8, 5, 465–469 (2007)
doi:10.1038/sj.embor.7400956
Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells
Alexander Wolf, Corinna Schmitz & Angelika Böttger
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Department of Biology II, Ludwig-Maximilians-University, Grosshaderner Strasse 2, D-82152 Planegg-Martinsried, Germany
To whom correspondence should be addressed
Angelika Böttger Tel: +49 89 2180 74 279; Fax: +49 89 2180 74 219;
boettger@zi.biologie.uni-muenchen.de
Received 18 December 2006; Accepted 14 March 2007.
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Abstract
The phosphatidylserine receptor (PSR) was originally described as the putative receptor for phosphatidylserine, which is displayed on the outer membrane leaflet of apoptotic cells as a so-called 'eat me' signal. Since then, contradictory findings about this protein have been published. A common characteristic of all PSR loss-of-function experiments in vertebrates has been neonatal lethality accompanied by severe developmental defects. However, impairment of phagocytosis has only been detected in some of these experiments. Furthermore, several groups have shown that PSR localizes to the nucleus. Structural in silico analysis of PSR indicates that it has a JumonjiC domain, and the molecular features characteristic of Fe(II)-dependent and 2-oxoglutarate-dependent oxygenases. This review summarizes the current status of research on the PSR protein.
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