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EMBO reports 8, 12, 1190–1195 (2007)
doi:10.1038/sj.embor.7401111
AOP Published online: 16 November 2007
Regulation of flowering time by the protein arginine methyltransferase AtPRMT10
Lifang Niu1, 2*, Falong Lu1, 2*, Yanxi Pei1, 3, Chunyan Liu1 & Xiaofeng Cao1
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1 State Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Beijing 100101, China
2 Graduate School, Chinese Academy of Sciences, Beijing 100039, China
3 College of Life Science and Technology, Shanxi University, Taiyuan 030006, China
To whom correspondence should be addressed
Xiaofeng Cao Tel: +86 10 64869203; Fax: +86 10 64873428; E-mail: xfcao@genetics.ac.cn
* These authors contributed equally to this work
Received 25 May 2007; Accepted 28 September 2007; Published online 16 November 2007.
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Abstract
In plants, histone H3 lysine methyltransferases are important in gene silencing and developmental regulation; however, the roles of histone H4 methylation in plant development remain unclear. Recent studies found a type II histone arginine methyltransferase, AtPRTM5, which is involved in promoting growth and flowering. Here, we purified a dimerized plant-specific histone H4 methyltransferase, plant histone arginine methyltransferase 10 (PHRMT10), from cauliflower. Arabidopsis thaliana protein arginine methyltransferase 10 (AtPRMT10)—the Arabidopsis homologue of PHRMT10—was shown to be a type I PRMT, which preferentially asymmetrically methylated histone H4R3 in vitro. Genetic disruption of AtPRMT10 resulted in late flowering by upregulating FLOWERING LOCUS C (FLC) transcript levels. In addition, we show that AtPRMT10 functions genetically separate from AtPRMT5, but that each acts to fine-tune expression of FLC. This work adds an extra layer of complexity to flowering-time regulation and also sheds light on the importance of asymmetric arginine methylation in plant development.
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