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EMBO reports 6, 1, 46–51 (2005)
doi:10.1038/sj.embor.7400317
Published online: 17 December 2004
Figure 5
The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments
Ingo Schwaiger, Michael Schleicher, Angelika A Noegel & Matthias Rief
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| Mechanical unfolding and refolding pathways in the energy landscape. (A) Schematic view of the ddFLN4 folding and unfolding energy landscape. The native state N and the intermediate state I correspond to minima in the energy landscape. The mechanical unfolding pathway (black line) and the folding pathway (red) are probably different. However, they both proceed through the same intermediate state. (B) Projection of the mechanical unfolding pathway on the mechanical reaction coordinate (N–C-terminal distance).
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