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EMBO reports 6, 1, 46–51 (2005)
doi:10.1038/sj.embor.7400317
Published online: 17 December 2004
Figure 3
The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments
Ingo Schwaiger, Michael Schleicher, Angelika A Noegel & Matthias Rief
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| Double-jump mechanical single-molecule experiment. (A) Time course of the mechanical extension (upper left) and corresponding force-extension curve of a single double jump. (B) Time course of the mechanical extension for a typical experiment running through 50 unfolding–refolding cycles (upper right). Lower right: superposition of the corresponding force-extension traces. Sample traces for the three possible outcomes of the refolding experiments are coloured in blue (complete refolding), red (refolding to the intermediate RFI) and orange (no refolding).
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