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EMBO reports 5, 7, 710–714 (2004)
doi:10.1038/sj.embor.7400189
Published online: 25 June 2004
Plexin-B3 is a functional receptor for semaphorin 5A
Stefania Artigiani, Paolo Conrotto, Pietro Fazzari, Giorgio F Gilestro, Davide Barberis, Silvia Giordano, Paolo M Comoglio & Luca Tamagnone
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Institute for Cancer Research and Treatment (IRCC), University of Torino—Medical School, 10060 Candiolo (TO), Italy
To whom correspondence should be addressed
Luca Tamagnone Tel: +39 011 9933204; Fax: +39 011 9933225; E-mail: luca.tamagnone@ircc.it
Received 19 September 2003; Accepted 18 May 2004; Published online 25 June 2004.
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Abstract
Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). In addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3. We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3.
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