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EMBO reports 5, 3, 241–244 (2004)
doi:10.1038/sj.embor.7400098
Published online: 20 February 2004
Figure 1
Signalling in stem cells
Meeting on Signal Transduction Determining the Fate of Stem
Cells
Lynn E. Heasley & Bryon E. Petersen
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Putative role of  -catenin in stem-cell renewal and maintenance
through cadherin-containing adherens junctions and Wnt signalling. Support
cells such as CAP cells, inner sheath cells or spindle-shaped
N-cadherin+CD45- osteoblastic (SNO) cells
form adherens junctions with germline stem cells, somatic stem cells or
haematopoietic stem cells (HSCs), respectively, through E-cadherin or
N-cadherin and -catenin (Lin, 2002). In
addition, -catenin can be stabilized as a result of Wnt signalling
through the frizzled (Fzd) receptors leading to the inhibition of the
APC–axin–GSK3- complex, allowing transcriptional activation
of target genes by T-cell factor (TCF)/-catenin complexes.
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