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EMBO reports 4, 6, 571–574 (2003)
doi:10.1038/sj.embor.embor867
IQGAP proteins are integral components of cytoskeletal regulation
Michael W. Briggs & David B. Sacks
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Brigham and Women's Hospital, Thorn 530, 75 Francis Street, Boston, Massachusetts 02115, USA
To whom correspondence should be addressed
David B. Sacks Tel:+1 617 732 6627; Fax: +1 617 278 6921; dsacks@rics.bwh.harvard.edu
Received 13 February 2003; Accepted 23 April 2003.
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Abstract
IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca2+/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E-cadherin-mediated cell–cell adhesion and  -catenin-mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.
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