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EMBO reports 4, 3, 246–251 (2003)
doi:10.1038/sj.embor.embor776
The Ark1/Prk1 family of protein kinases
Regulators of endocytosis and the actin cytoskeleton
Elizabeth Smythe1 & Kathryn R. Ayscough2
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1 Centre for Developmental Genetics, Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, UK
2 Department of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK
To whom correspondence should be addressed
Elizabeth Smythe Tel: +44 114 222 4635; Fax: +44 114 222 2788; e.smythe@sheffield.ac.uk
Received 12 December 2002; Accepted 22 January 2003; Published online 28 February 2003.
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Abstract
The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evolution of Ark/Prk family members in different organisms may have allowed the conserved role of the kinase domain, which is required for the phosphorylation of both endocytic and cytoskeletal components, to be coupled to other functional domains.
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