|
 |
|
|
|
EMBO reports 4, 1, 31–36 (2003)
doi:10.1038/sj.embor.embor704
NF- B activation by protein kinase C isoforms and B-cell function
Jorge Moscat1, María T. Diaz-Meco1 & Paul Rennert2
|
|
|
|
1 Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
2 Biogen, Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
To whom correspondence should be addressed
Jorge Moscat Tel: +34 913978039; Fax: +34 917616184; jmoscat@cbm.uam.es
Received 18 September 2002; Accepted 28 October 2002.
|
|
|
|
Abstract
B cells are essential to the immune response in health and disease. Results from knockout (KO) mice for different members of the nuclear factor-B (NF-B) family have highlighted the importance of this transcription factor in B cell development and function. The recent generation of additional KO mice for adapters and kinases implicated in NF-B activation, including several protein kinase C isoforms, has provided new insights into the roles of these proteins in B cell signalling. These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-B.
|
|
top  |
|
|
|
