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EMBO reports 3, 4, 319–322 (2002)
doi:10.1093/embo-reports/kvf075
Chromatin remodeling enzymes: taming the machines
Third in review series on chromatin dynamics
Craig L. Peterson
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Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA Tel: +1 508 856 5858; Fax: +1 508 856 5011; e-mail: craig.peterson@umassmed.edu
Received 9 January 2002; Accepted 18 February 2002.
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Abstract
Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle. Each of these enzymes are multi-subunit assemblies that hydrolyze thousands of molecules of ATP in order to change nucleosome positions, disrupt DNA–histone interactions and perhaps destabilize chromatin folding. Here I review recent studies that suggest these potent machines can be 'tamed' by one of several mechanisms: targeting their activity to localized regions, blocking their chromatin binding activity or inhibiting their remodeling activity.
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