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EMBO reports 2, 10, 893–898 (2001)
doi:10.1093/embo-reports/kve208
Irresistible IRES
Attracting the translation machinery to internal ribosome entry sites
Stéphan Vagner1, Bruno Galy2 & Stéphane Pyronnet3
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1 INSERM U397, Institut Louis Bugnard, CHU Rangueil, 31403 Toulouse, France
2 EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
3 INSERM U531, Institut Louis Bugnard, CHU Rangueil, 31403 Toulouse, France
To whom correspondence should be addressed
Stéphan Vagner Tel: +33 561 32 31 28; Fax: +33 561 32 21 41; vagner@rangueil.inserm.fr
Received 18 May 2001; Accepted 28 August 2001.
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Abstract
Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.
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