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Welcome to EMBO reports
EMBO reports is a print and online publication dedicated to providing a variety of sharply focused and rapidly published short papers and review articles in all areas of molecular biology. Its quality is reflected in its impact factor of 8.175*
*Journal Citation Reports, Thomson 2007
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An open challenge 
The grand impact of the Gates Foundation
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Science and Society in full... |
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The PeptideAtlas project
Singlet oxygen signalling in plants
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Reviews in full... |
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‘Insulator bodies’ are non-insulating aggregates
It is thought that regulatory genomic elements known as insulators function by forming aggregates called insulator bodies that fold chromatin into rosette-like structures. The Georgiev lab now challenges this assumption by demonstrating that a mutant of Mod(mdg4) that cannot enter these bodies is an effective insulator, whereas a mutant that enters the bodies but cannot interact with Su(Hw) has no insulator function. Thus, the authors conclude that bona fide insulators are independent of insulator bodies, which might instead be protein aggregates not directly engaged in insulating.
COPR5 is required for PRMT5 nuclear functions
Lacroix et al identify a new nuclear protein called COPR5 that binds methyltransferase PRMT5 and modulates the substrate specificity of PRMT5 complexes. COPR5 also binds histone H4 and is required to recruit PRMT5 to nucleosomes in specific sites, such as the cyclin E1 promoter. Together, these results characterize COPR5 as a novel PRMT5 chromatin adaptor.
TRPP2 and TRPC1 interact to form a new channel
A novel TRP channel, formed by TRPP2 and TRPC1in kidney cells, is characterized by the Delmas group in this report. This channel is activated in response to a G-protein coupled receptor and its biophysical properties differ from those of TRPP2 and TRPC1 homomeric channels. The identification and characterization of the TRPP2/TRPC1 channel could help to understand the pathology underlying 15% of autosomal dominant polycystic disease cases, which are caused by mutations in TRPP2.
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 Science and Society Special Issue
Volume 8, July 2007
Genes, brain/mind and behaviour
Click here to view Special Issue
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