Advance online publication

The latest research papers brought to you ahead of print publication by The EMBO Journal AOP. These online versions are definitive and may be cited using the digital object identifier (DOI).

About advance online publication

05 November 2009
29 October 2009
22 October 2009
15 October 2009
08 October 2009
01 October 2009
24 September 2009
10 September 2009

05 November 2009
Top of page
- How tropomyosin regulates lamellipodial actin-based motility: a combined biochemical and reconstituted motility approach
  Beáta Bugyi, Dominique Didry and Marie-France Carlier
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.316
  Published online: 05 November 2009
  Subject Category:
  - Cell and Tissue Architecture
- Tipin/Tim1/And1 protein complex promotes Pol chromatin binding and sister chromatid cohesion EMBO Open
  Alessia Errico, Claudia Cosentino, Teresa Rivera, Ana Losada, Etienne Schwob, Tim Hunt and Vincenzo Costanzo
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.304
  Published online: 05 November 2009
  Subject Category:
  - Genome Stability and Dynamics
- Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene
  Toshio Maekawa, Seungjoon Kim, Daisuke Nakai, Chieko Makino, Tsuyoshi Takagi, Hiroo Ogura, Kazuyuki Yamada, Bruno Chatton and Shunsuke Ishii
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.318
  Published online: 05 November 2009
  Subject Categories:
  - Chromatin and Transcription | Neuroscience
- Crystal structure of A₃B₃ complex of V-ATPase from Thermus thermophilus EMBO Open
  Megan J Maher, Satoru Akimoto, Momi Iwata, Koji Nagata, Yoshiko Hori, Masasuke Yoshida, Shigeyuki Yokoyama, So Iwata and Ken Yokoyama
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.310
  Published online: 05 November 2009
  Subject Categories:
  - Proteins | Structural Biology
- Strain through the neck linker ensures processive runs: a DNA-kinesin hybrid nanomachine study EMBO Open
  Yuya Miyazono, Masahito Hayashi, Peter Karagiannis, Yoshie Harada and Hisashi Tadakuma
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.319
  Published online: 05 November 2009
  Subject Categories:
  - Membranes and Transport | Proteins
- Immature small ribosomal subunits can engage in translation initiation in Saccharomyces cerevisiae
  Julien Soudet, Jean-Paul Gélugne, Kamila Belhabich-Baumas, Michèle Caizergues-Ferrer and Annie Mougin
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.307
  Published online: 05 November 2009
  Subject Category:
  - Proteins
- The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module EMBO Open
  Shin-ichi Terawaki, Ken Kitano, Tomoyuki Mori, Yan Zhai, Yoshiki Higuchi, Norimichi Itoh, Takashi Watanabe, Kozo Kaibuchi and Toshio Hakoshima
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.323
  Published online: 05 November 2009
  Subject Categories:
  - Signal Transduction | Structural Biology
- Coordinated regulation of autophagy by p38 MAPK through mAtg9 and p38IP
  Jemma L Webber and Sharon A Tooze
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.321
  Published online: 05 November 2009
  Subject Categories:
  - Membranes and Transport | Signal Transduction
- CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin EMBO Open
  Sara A Wickström, Katarzyna C Masoumi, Saadi Khochbin, Reinhard Fässler and Ramin Massoumi
  The EMBO Journal advance online publication 05 November 2009;
  doi:10.1038/emboj.2009.317
  Published online: 05 November 2009
  Subject Categories:
  - Cell and Tissue Architecture | Cell Cycle
29 October 2009
Top of page
- The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
  Makiko Koike-Kumagai, Kei-ichiro Yasunaga, Rei Morikawa, Takahiro Kanamori and Kazuo Emoto
  The EMBO Journal advance online publication 29 October 2009;
  doi:10.1038/emboj.2009.312
  Published online: 29 October 2009
  Subject Categories:
  - Development | Neuroscience
- Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction
  Marina L Kozak, Alejandro Chavez, Weiwei Dang, Shelley L Berger, Annie Ashok, Xiaoge Guo and F Brad Johnson
  The EMBO Journal advance online publication 29 October 2009;
  doi:10.1038/emboj.2009.314
  Published online: 29 October 2009
  Subject Categories:
  - Chromatin and Transcription | Genome Stability and Dynamics
- Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/-synuclein complex by Hip
  Cintia Roodveldt, Carlos W Bertoncini, August Andersson, Annemieke T van der Goot, Shang-Te Hsu, Rafael Fernández-Montesinos, Jannie de Jong, Tjakko J van Ham, Ellen A Nollen, David Pozo, John Christodoulou and Christopher M Dobson
  The EMBO Journal advance online publication 29 October 2009;
  doi:10.1038/emboj.2009.298
  Published online: 29 October 2009
  Subject Categories:
  - Proteins | Molecular Biology of Disease
22 October 2009
Top of page
- The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo EMBO Open
  Hasna Boubakri, Anne Langlois de Septenville, Enrique Viguera and Bénédicte Michel
  The EMBO Journal advance online publication 22 October 2009;
  doi:10.1038/emboj.2009.308
  Published online: 22 October 2009
  Subject Category:
  - Genome Stability and Dynamics
- Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK
  Benu Brata Das, Smitha Antony, Shalu Gupta, Thomas S Dexheimer, Christophe E Redon, Susan Garfield, Yosef Shiloh and Yves Pommier
  The EMBO Journal advance online publication 22 October 2009;
  doi:10.1038/emboj.2009.302
  Published online: 22 October 2009
  Subject Category:
  - Genome Stability and Dynamics
- Inhibition of the shade avoidance response by formation of non-DNA binding bHLH heterodimers
  Patricia Hornitschek, Séverine Lorrain, Vincent Zoete, Olivier Michielin and Christian Fankhauser
  The EMBO Journal advance online publication 22 October 2009;
  doi:10.1038/emboj.2009.306
  Published online: 22 October 2009
  Subject Category:
  - Plant Biology
- Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules
  Christopher Howe, Malgorzata Garstka, Mohammed Al-Balushi, Esther Ghanem, Antony N Antoniou, Susanne Fritzsche, Gytis Jankevicius, Nasia Kontouli, Clemens Schneeweiss, Anthony Williams, Tim Elliott and Sebastian Springer
  The EMBO Journal advance online publication 22 October 2009;
  doi:10.1038/emboj.2009.296
  Published online: 22 October 2009
  Subject Categories:
  - Membranes and Transport | Immunology
- Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification
  Massimo Nichane, Xi Ren and Eric J Bellefroid
  The EMBO Journal advance online publication 22 October 2009;
  doi:10.1038/emboj.2009.313
  Published online: 22 October 2009
  Subject Categories:
  - Signal Transduction | Development
- Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5 EMBO Open
  Joanne L Parker and Helle D Ulrich
  The EMBO Journal advance online publication 22 October 2009;
  doi:10.1038/emboj.2009.303
  Published online: 22 October 2009
  Subject Categories:
  - Proteins | Genome Stability and Dynamics
- Neural stem cell transcriptional networks highlight genes essential for nervous system development EMBO Open
  Tony D Southall and Andrea H Brand
  The EMBO Journal advance online publication 22 October 2009;
  doi:10.1038/emboj.2009.309
  Published online: 22 October 2009
  Subject Categories:
  - Chromatin and Transcription | Development
15 October 2009
Top of page
- 4E-BP1 is a target of Smad4 essential for TGF-mediated inhibition of cell proliferation
  Rania Azar, Amandine Alard, Christiane Susini, Corinne Bousquet and Stéphane Pyronnet
  The EMBO Journal advance online publication 15 October 2009;
  doi:10.1038/emboj.2009.291
  Published online: 15 October 2009
  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila
  Reinhard Bauer, André Voelzmann, Bernadette Breiden, Ute Schepers, Hany Farwanah, Ines Hahn, Franka Eckardt, Konrad Sandhoff and Michael Hoch
  The EMBO Journal advance online publication 15 October 2009;
  doi:10.1038/emboj.2009.305
  Published online: 15 October 2009
  Subject Category:
  - Cellular Metabolism
- Histone H1 binding is inhibited by histone variant H3.3
  Ulrich Braunschweig, Greg J Hogan, Ludo Pagie and Bas van Steensel
  The EMBO Journal advance online publication 15 October 2009;
  doi:10.1038/emboj.2009.301
  Published online: 15 October 2009
  Subject Category:
  - Chromatin and Transcription
- Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour
  Sachiko Taniguchi, Takanobu Nakazawa, Asami Tanimura, Yuji Kiyama, Tohru Tezuka, Ayako M Watabe, Norikazu Katayama, Kazumasa Yokoyama, Takeshi Inoue, Hiroko Izumi-Nakaseko, Shigeru Kakuta, Katsuko Sudo, Yoichiro Iwakura, Hisashi Umemori, Takafumi Inoue, Niall P Murphy, Kouichi Hashimoto, Masanobu Kano, Toshiya Manabe and Tadashi Yamamoto
  The EMBO Journal advance online publication 15 October 2009;
  doi:10.1038/emboj.2009.300
  Published online: 15 October 2009
  Subject Categories:
  - Signal Transduction | Neuroscience
08 October 2009
Top of page
- A loop-to-base processing mechanism underlies the biogenesis of plant microRNAs miR319 and miR159
  Nicolás G Bologna, Julieta L Mateos, Edgardo G Bresso and Javier F Palatnik
  The EMBO Journal advance online publication 08 October 2009;
  doi:10.1038/emboj.2009.292
  Published online: 08 October 2009
  Subject Categories:
  - RNA | Plant Biology
- ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
  Qian Cheng, Lihong Chen, Zhenyu Li, William S Lane and Jiandong Chen
  The EMBO Journal advance online publication 08 October 2009;
  doi:10.1038/emboj.2009.294
  Published online: 08 October 2009
  Subject Categories:
  - Cell and Tissue Architecture | Genome Stability and Dynamics
- Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands
  William C Florence, Chengfeng Xia, Laura E Gordy, Wenlan Chen, Yalong Zhang, James Scott-Browne, Yuki Kinjo, Karl O A Yu, Santosh Keshipeddy, Daniel G Pellicci, Onisha Patel, Lars Kjer-Nielsen, James McCluskey, Dale I Godfrey, Jamie Rossjohn, Stewart K Richardson, Steven A Porcelli, Amy R Howell, Kyoko Hayakawa, Laurent Gapin, Dirk M Zajonc, Peng George Wang and Sebastian Joyce
  The EMBO Journal advance online publication 08 October 2009;
  doi:10.1038/emboj.2009.286
  Published online: 08 October 2009
  Subject Category:
  - Immunology
- TOC1 functions as a molecular switch connecting the circadian clock with plant responses to drought
  Tommaso Legnaioli, Juan Cuevas and Paloma Mas
  The EMBO Journal advance online publication 08 October 2009;
  doi:10.1038/emboj.2009.297
  Published online: 08 October 2009
  Subject Categories:
  - Chromatin and Transcription | Plant Biology
- Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn
  So-Hee Lim, Seok-Kyu Kwon, Myung Kyu Lee, Jeonghee Moon, Dae Gwin Jeong, Eunha Park, Seung Jun Kim, Byung Chul Park, Sang Chul Lee, Seong-Eon Ryu, Dae-Yeul Yu, Bong Hyun Chung, Eunjoon Kim, Pyung-Keun Myung and Jae-Ran Lee
  The EMBO Journal advance online publication 08 October 2009;
  doi:10.1038/emboj.2009.289
  Published online: 08 October 2009
  Subject Categories:
  - Signal Transduction | Neuroscience
01 October 2009
Top of page
- The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
  Nicholas J Anthis, Kate L Wegener, Feng Ye, Chungho Kim, Benjamin T Goult, Edward D Lowe, Ioannis Vakonakis, Neil Bate, David R Critchley, Mark H Ginsberg and Iain D Campbell
  The EMBO Journal advance online publication 01 October 2009;
  doi:10.1038/emboj.2009.287
  Published online: 01 October 2009
  Subject Categories:
  - Signal Transduction | Structural Biology
- Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the -subunit
  Brandy Barren, Lokesh Gakhar, Hakim Muradov, Kimberly K Boyd, S Ramaswamy and Nikolai O Artemyev
  The EMBO Journal advance online publication 01 October 2009;
  doi:10.1038/emboj.2009.284
  Published online: 01 October 2009
  Subject Categories:
  - Signal Transduction | Structural Biology
- Mg²⁺-dependent gating of bacterial MgtE channel underlies Mg²⁺ homeostasis
  Motoyuki Hattori, Norihiko Iwase, Noritaka Furuya, Yoshiki Tanaka, Tomoya Tsukazaki, Ryuichiro Ishitani, Michael E Maguire, Koichi Ito, Andres Maturana and Osamu Nureki
  The EMBO Journal advance online publication 01 October 2009;
  doi:10.1038/emboj.2009.288
  Published online: 01 October 2009
  Subject Categories:
  - Membranes and Transport | Structural Biology
- Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor EMBO Open
  Ning Sheng Liu, Li Shen Loo, Eva Loh, Li-Fong Seet and Wanjin Hong
  The EMBO Journal advance online publication 01 October 2009;
  doi:10.1038/emboj.2009.282
  Published online: 01 October 2009
  Subject Categories:
  - Membranes and Transport | Signal Transduction
- AP-2 promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene
  Christopher M J Williams, Angelo G Scibetta, J Karsten Friedrich, Monica Canosa, Chiara Berlato, Charlotte H Moss and Helen C Hurst
  The EMBO Journal advance online publication 01 October 2009;
  doi:10.1038/emboj.2009.290
  Published online: 01 October 2009
  Subject Category:
  - Molecular Biology of Disease
24 September 2009
Top of page
- A ribosome–nascent chain sensor of membrane protein biogenesis in Bacillus subtilis
  Shinobu Chiba, Anne Lamsa and Kit Pogliano
  The EMBO Journal advance online publication 24 September 2009;
  doi:10.1038/emboj.2009.280
  Published online: 24 September 2009
  Subject Categories:
  - Membranes and Transport | Proteins
- PARP-1 transcriptional activity is regulated by sumoylation upon heat shock
  Nadine Martin, Klaus Schwamborn, Valérie Schreiber, Andreas Werner, Christelle Guillier, Xiang-Dong Zhang, Oliver Bischof, Jacob-S Seeler and Anne Dejean
  The EMBO Journal advance online publication 24 September 2009;
  doi:10.1038/emboj.2009.279
  Published online: 24 September 2009
  Subject Categories:
  - Chromatin and Transcription | Proteins
- The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans
  Bettina Meier, Louise J Barber, Yan Liu, Ludmila Shtessel, Simon J Boulton, Anton Gartner and Shawn Ahmed
  The EMBO Journal advance online publication 24 September 2009;
  doi:10.1038/emboj.2009.278
  Published online: 24 September 2009
  Subject Category:
  - Genome Stability and Dynamics
- Curved FtsZ protofilaments generate bending forces on liposome membranes
  Masaki Osawa, David E Anderson and Harold P Erickson
  The EMBO Journal advance online publication 24 September 2009;
  doi:10.1038/emboj.2009.277
  Published online: 24 September 2009
  Subject Categories:
  - Membranes and Transport | Structural Biology
- RNase Y, a novel endoribonuclease, initiates riboswitch turnover in Bacillus subtilis
  Karen Shahbabian, Ailar Jamalli, Léna Zig and Harald Putzer
  The EMBO Journal advance online publication 24 September 2009;
  doi:10.1038/emboj.2009.283
  Published online: 24 September 2009
  Subject Categories:
  - RNA | Cellular Metabolism
10 September 2009
Top of page
- SnoN functions as a tumour suppressor by inducing premature senescence
  Deng Pan, Qingwei Zhu and Kunxin Luo
  The EMBO Journal advance online publication 10 September 2009;
  doi:10.1038/emboj.2009.250
  Published online: 10 September 2009
  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease

Advance online publication

05 November 2009

How tropomyosin regulates lamellipodial actin-based motility: a combined biochemical and reconstituted motility approach

Subject Category:

Tipin/Tim1/And1 protein complex promotes Pol chromatin binding and sister chromatid cohesion EMBO Open

Subject Category:

Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene

Subject Categories:

Crystal structure of A3B3 complex of V-ATPase from Thermus thermophilus EMBO Open

Subject Categories:

Strain through the neck linker ensures processive runs: a DNA-kinesin hybrid nanomachine study EMBO Open

Subject Categories:

Immature small ribosomal subunits can engage in translation initiation in Saccharomyces cerevisiae

Subject Category:

The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module EMBO Open

Subject Categories:

Coordinated regulation of autophagy by p38 MAPK through mAtg9 and p38IP

Subject Categories:

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin EMBO Open

Subject Categories:

29 October 2009

The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway

Subject Categories:

Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction

Subject Categories:

Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/-synuclein complex by Hip

Subject Categories:

22 October 2009

The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo EMBO Open

Subject Category:

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

Subject Category:

Inhibition of the shade avoidance response by formation of non-DNA binding bHLH heterodimers

Subject Category:

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules

Subject Categories:

Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification

Subject Categories:

Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5 EMBO Open

Subject Categories:

Neural stem cell transcriptional networks highlight genes essential for nervous system development EMBO Open

Subject Categories:

15 October 2009

4E-BP1 is a target of Smad4 essential for TGF-mediated inhibition of cell proliferation

Subject Categories:

schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila

Subject Category:

Histone H1 binding is inhibited by histone variant H3.3

Subject Category:

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

Subject Categories:

08 October 2009

A loop-to-base processing mechanism underlies the biogenesis of plant microRNAs miR319 and miR159

Subject Categories:

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

Subject Categories:

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

Subject Category:

TOC1 functions as a molecular switch connecting the circadian clock with plant responses to drought

Subject Categories:

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn

Subject Categories:

01 October 2009

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

Subject Categories:

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the -subunit

Subject Categories:

Mg2+-dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis

Subject Categories:

Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor EMBO Open

Subject Categories:

AP-2 promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene

Subject Category:

24 September 2009

A ribosome–nascent chain sensor of membrane protein biogenesis in Bacillus subtilis

Subject Categories:

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

Subject Categories:

The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

Subject Category:

Crystal structure of A₃B₃ complex of V-ATPase from Thermus thermophilus EMBO Open

Mg²⁺-dependent gating of bacterial MgtE channel underlies Mg²⁺ homeostasis