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  • The EMBO Journal (2008) 27, 2353 - 2362
  • doi:10.1038/emboj.2008.160

Published online: 21 August 2008

Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune functionEMBO Open

Istvan Szatmari1 and Laszlo Nagy1,2

  1. Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
  2. Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

Correspondence to:

Laszlo Nagy, Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, Medical and Health Science Center, Life Science Building, University of Debrecen, Egyetem ter 1, Debrecen 4010, Hungary. Tel.: +36 52 416 432; Fax: +36 52 314 989; E-mail: lnagy@indi.biochem.dote.hu

Received 23 April 2008; Accepted 24 July 2008

Dendritic cells (DCs) are sentinels of the immune system and represent a heterogeneous cell population. The existence of distinct DC subsets is due to their inherent plasticity and to the changing microenvironment modulating their immunological properties. Numerous signalling pathways have impacts on DCs. It appears that besides cytokines/chemokines, lipid mediators also have profound effects on the immunogenicity of DCs. Some of these lipid mediators exert an effect through nuclear hormone receptors. Interestingly, more recent findings suggest that DCs are able to convert precursors to active hormones, ligands for nuclear receptors. Some of these DC-derived lipids, in particular retinoic acid (RA), have a central function in shaping T-cell development and effector functions. In this review, we summarize and highlight the function of a set of nuclear receptors (PPARgamma, RA receptor, vitamin D receptor and glucocorticoid receptor) in DC biology. Defining the contribution of nuclear hormone receptor signalling in DCs can help one to understand the regulatory logic of lipid signalling and allow the exploitation of their potential for therapeutic intervention in various immunological diseases.

  • Keywords:

    • dendritic cells,
    • immunity,
    • lipid signalling,
    • nuclear receptors,
    • PPARgamma

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