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Figure 3

Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism

Daniel C Lee, Jimin Zheng, Yi-Min She and Zongchao Jia

  • The EMBO Journal (2008) 27, 1758 - 1766
  • doi:10.1038/emboj.2008.97

Published online: 22 May 2008

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Sequence alignment of prokaryotic Tyr kinases and MinD ATPases. The ATP-binding Walker motifs (green shades) are conserved among all sequences. The C-terminal Tyr-cluster is conserved among bacterial Tyr kinases but not ATPases. The two important residues for Etk activation, Y574 and R614, are only present in Gram-negative Tyr kinases.

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