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Figure 5

Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes

Andrey V Pisarev, Victoria G Kolupaeva, Marat M Yusupov, Christopher UT Hellen and Tatyana V Pestova

  • The EMBO Journal (2008) 27, 1609 - 1621
  • doi:10.1038/emboj.2008.90

Published online: 8 May 2008

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Ribosomal proteins crosslinked to different positions of mRNA in 48S/80S initiation complexes mapped onto the crystal structure of the mRNA/T. thermophilus 30S subunit complex (Yusupova et al, 2006; PDB code 2HGR): (A) intersubunit side view and (B) solvent side view. mRNA (coral), 16S rRNA (gray) and ribosomal proteins (light blue or coloured) are in ribbon representation. The positions of mRNA nucleotides that crosslink to ribosomal proteins or eIF3 are shown as coloured spheres. colours of nucleotide positions in mRNA correspond to colours of crosslinked proteins. Light blue spheres represent nucleotides in 18S rRNA that are protected or cleaved in eIF3/40S subunit complexes.

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