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The EMBO Journal (2008) 27, 1563–1574, doi:10.1038/emboj.2008.85 Published online 1 May 2008 Figure 1 Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation Axel Weber, Judith Marquardt, David Elzi, Nicole Forster, Sven Starke, Andre Glaum, Daisuke Yamada, Pierre-Antoine Defossez, Jeffrey Delrow, Robert N Eisenman, Holger Christiansen and Martin Eilers

Figure 1 Expression of ZBTB4 mRNA in human tumours. (A) ZBTB4 is expressed in a stage-dependent manner in human neuroblastoma. The graph is a summary of microarray data of ZBTB4 mRNA levels observed in different neuroblastoma tumour stages. The data are taken from the original analysis (Berwanger et al, 2002). Error bars represent standard error of the mean. (B) Confirmation of microarray data. The graph summarizes the RQ–PCR analysis of ZBTB4 expression in an independent set of 98 primary neuroblastoma tumours. Error bars represent standard error of the mean. (C) Expression of ZBTB4 correlates with patient survival. The graph documents the Kaplan–Meier analysis of neuroblastoma patients with ZBTB4 mRNA expression levels above ('high') and below ('low') the mean expression level. (D) ZBTB4 is repressed in glioblastoma and in prostate carcinoma relative to normal tissue. The data are taken from the studies summarized in Table 1, and were obtained from www.oncomine.org. The numbers refer to Table 1. In this and the following panel, data are presented as Box and Whisker graph with error bars representing the 5th and 95th percentile. (E) Stage-specific expression of ZBTB4 in breast and prostate carcinoma. The data are taken from the studies summarized in Table 2. The plots are taken from www.oncomine.org (BH, benign hyperplasia; IN, intraepithelial hyperplasia; LPC, localized prostate carcinoma; MPC, prostate carcinoma metastasis).

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