Figure 1
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
Dirk Heitzmann, Renaud Derand, Stefan Jungbauer, Sascha Bandulik, Christina Sterner, Frank Schweda, Abeer El Wakil, Enzo Lalli, Nicolas Guy, Raymond Mengual, Markus Reichold, Ines Tegtmeier, Saïd Bendahhou, Celso E Gomez-Sanchez, M Isabel Aller, William Wisden, Achim Weber, Florian Lesage, Richard Warth and Jacques Barhanin
- The EMBO Journal (2008) 27, 179 - 187
- doi:10.1038/sj.emboj.7601934
Published online: 22 November 2007
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Aldosterone levels in task1 -/- mice. Plasma aldosterone levels of adult female (A) and male (B) mice on various salt diets are shown. In female task1 +/+ (+/+) and task1 +/- (+/-) mice, aldosterone concentrations are not different from each other under the three diet conditions (P=0.679), whereas they are considerably higher (P<0.0001) in task1 -/- mice (-/-). In males, aldosterone levels varied with the diet independently from the genotype (P>0.1). The numbers of female mice per genotype were 11–27 (+/+), 13–15 (+/-), and 17–32 (-/-). Corresponding numbers for males were 10–27 (+/+), 3–9 (+/-), and 9–23 (-/-). NK: normal K+ (0.75%) diet; HK: high-K+ (3%) diet; LK: low-K+ (0.05%) diet; LNa: low-Na+ (<0.005%) diet. *Indicates statistically different from normal K+ diet (NK) or between the groups as indicated. NS: not significantly different.
