EMBO Members Review
- The EMBO Journal (2008) 27, 1 - 5
- doi:10.1038/sj.emboj.7601945
Published online: 29 November 2007
Subject Categories:
MHC class II molecules on the move for successful antigen presentation
Nuno Rocha1 and Jacques Neefjes1
- Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Correspondence to:
Jacques Neefjes, Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands. Tel.: +31 20 5122012; Fax: +31 20 5122029; E-mail: J.NEEFJES@NKI.NL
Received 10 October 2007; Accepted 12 November 2007
Abstract
Major histocompatibility complex class II (MHC II) molecules are targeted to endocytic compartments, known as MIIC, by the invariant chain (Ii) that is degraded upon arrival in these compartments. MHC II acquire antigenic fragments from endocytosed proteins for presentation at the cell surface. In a unique and complex series of reactions, MHC II succeed in exchanging a remaining fragment of Ii for other protein fragments in subdomains of MIIC before transport to the cell surface. Here, the mechanisms regulating loading and intracellular trafficking of MHC II are discussed.
Keywords:
- intracellular transport,
- MHC class II,
- MIIC,
- motor proteins,
- Rab7
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