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| Subject Categories: Neuroscience |
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| The EMBO Journal
(2008) 27, 188–200, doi:10.1038/sj.emboj.7601939 Published online 29 November 2007 |
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Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP |
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| Haihong Ye1, Yen Ling Jessie Tan1, Sathivel Ponniah2, Yasuo Takeda3, Shi-Qiang Wang4, Melitta Schachner5, 6, Kazutada Watanabe7, Catherine J Pallen8 and Zhi-Cheng Xiao1, 9 |
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1 Institute of Molecular and Cell Biology, Singapore 2 BRC, A*STAR, Singapore 3 Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan 4 State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University College of Life Sciences, Beijing, China 5 Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA 6 Sino-German Center for Neuroscience, Dalian Medical University, Dalian, China 7 Department of BioEngineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan 8 Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada 9 Department of Clinical Research, Singapore General Hospital, Singapore To whom correspondence should be addressed Zhi-Cheng Xiao, Department of Clinical Research, Singapore General Hospital, Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Proteos, Singapore 138673, Singapore. Tel.: +65 6326 6195; Fax: +65 6321 3606; E-mail: xiao.zhi.cheng@sgh.com.sg or zcxiao@imcb.a-star.edu.sg Received 25 June 2007; Accepted 7 November 2007; Published online 29 November 2007. |
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| Abstract |
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| Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. Neural recognition molecule Close Homolog of L1 (CHL1) has been shown to regulate oriented growth of apical dendrites in the mouse caudal cortex. Here we show that CHL1 directly associates with NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. Similar to CHL1, NB-3 exhibits high-caudal to low-rostral expression in the deep layer neurons of the neocortex. NB-3-deficient mice show abnormal apical dendrite projections of deep layer pyramidal neurons in the visual cortex. Both CHL1 and NB-3 interact with protein tyrosine phosphatase (PTP) and regulate its activity. Moreover, deep layer pyramidal neurons of PTP-deficient mice develop misoriented, even inverted, apical dendrites. We propose a signaling complex in which PTP mediates CHL1 and NB-3-regulated apical dendrite projection in the developing caudal cortex. |
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| Keywords: adhesion, dendrite development, p59fyn |
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