|
 |
|
|
| Subject Categories: Chromatin & Transcription | Plant Biology |
|
| The EMBO Journal
(2007) 26, 1934–1941, doi:10.1038/sj.emboj.7601647 Published online 15 March 2007 |
|
| SKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in Arabidopsis |
|
|
| Xin Wang1, 4, Ya Zhang1, 4, Qibin Ma2, Zhaoliang Zhang1, Yongbiao Xue1, 3, Shilai Bao1 and Kang Chong2, 3 |
|
|
1 Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 2 Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, China 3 National Plant Gene Research Centre, Beijing, China To whom correspondence should be addressed Shilai Bao, Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China. Tel.: +86 10 64889350; Fax: +86 10 64889350; E-mail: slbao@genetics.ac.cn Kang Chong, Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Xiangshan, Beijing 100093, China. Tel.: +86 10 62836517; Fax: +86 10 82594821; E-mail: chongk@ibcas.ac.cn 4 These authors contributed equally to this work Received 3 November 2006; Accepted 20 February 2007; Published online 15 March 2007. |
|
|
|
| Abstract |
|
| Plant flowering is a crucial developmental transition from the vegetative to reproductive phase and is properly timed by a number of intrinsic and environmental cues. Genetic studies have identified that chromatin modification influences the expression of FLOWERING LOCUS C (FLC), a MADS-box transcription factor that controls flowering time. Histone deacetylation and methylation at H3K9 and H3K27 are associated with repression of FLC; in contrast, methylation at H3K4 and H3K36 activates FLC expression. However, little is known about the functions of histone arginine methylation in plants. Here, we report that Arabidopsis Shk1 binding protein 1 (SKB1) catalyzes histone H4R3 symmetric dimethylation (H4R3sme2). SKB1 lesion results in upregulation of FLC and late flowering under both long and short days, but late flowering is reversed by vernalization and gibberellin treatments. An skb1-1flc-3 double mutant blocks late-flowering phenotype, which suggests that SKB1 promotes flowering by suppressing FLC transcription. SKB1 binds to the FLC promoter, and disruption of SKB1 results in reduced H4R3sme2, especially in the promoter of FLC chromatin. Thus, SKB1-mediated H4R3sme2 is a novel histone mark required for repression of FLC expression and flowering time control. |
|
| Keywords: FLC, flowering time, histone arginine methylation, PRMT5/SKB1 |
|
|
|
Top of page MORE ARTICLES LIKE THISThese links to content published by NPG are automatically generated NEWS AND VIEWSNature Genetics News and Views (01 Feb 2004) Plant development The flowers that bloom in the spring Nature News and Views (08 Jan 2004) RESEARCHSKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in Arabidopsis The EMBO Journal Article Autoregulation of FCA pre-mRNA processing controls Arabidopsis flowering time The EMBO Journal Article (16 Jun 2003) |
|
|
| |
| |
| |
 | Email link to a friend |
| |
 | Download PDF |
| |
 | Full text |
| |
| |
| |
 | Next article |
| |
 | Previous article |
| |
 | Table of contents |
| |
| |
 | Rights and permissions |
| |
 | Reprints |
| |
| |
| |
 Register for table of contents by email | |
| |
| |
| |