Article
- The EMBO Journal (2007) 26, 752 - 763
- doi:10.1038/sj.emboj.7601541
Published online: 25 January 2007
Subject Categories:
Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control
Norman G Nagl Jr1, Xiaomei Wang1, Antonia Patsialou1, Michael Van Scoy1 and Elizabeth Moran1
- Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA
Correspondence to:
Elizabeth Moran, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA. Tel.: +1 215 707 7313; Fax: +1 215 707 6989; E-mail: betty@temple.edu
Received 27 June 2006; Accepted 4 December 2006
Abstract
The mammalian SWI/SNF chromatin remodeling complex is becoming increasingly recognized for its role in tumor suppression, based on its ability to regulate accessibility of proliferation-associated genes to transcription factors. However, understanding the biological role of the complex is complicated because the same complex seemingly plays both positive and negative roles in gene expression. Work described here reveals that a choice between two independently encoded, closely related variants of a major subunit of the ARID protein family determines whether the SWI/SNF complex forms further associations with activator versus repressor complexes. The choice distinguishes assemblies with opposite effects on cell-cycle activity. The specific complexes control access of factors such as E2F1, Tip60, and HDAC1/2/3 to the promoters of various cell-cycle-specific genes, with c-Myc emerging as a particularly critical target.
Keywords:
- cell cycle,
- c-Myc,
- chromatin remodeling,
- E2F,
- SWI/SNF
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