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The EMBO Journal (2007) 26, 380–390, doi:10.1038/sj.emboj.7601484 Published online 21 December 2006 Figure 6 Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation Xi Luo, Oscar Puig, Joogyung Hyun, Dirk Bohmann and Heinrich Jasper

Figure 6 Model for the regulation of UV-induced apoptosis in the Drosophila retina. JNK activation results in Foxo- and Fos-dependent transcriptional upregulation of hid. Hid inhibits IAP and induces caspase-dependent apoptosis. Induction of hid can be blocked by InR or EGFR-initiated survival signals that inhibit Foxo activity. The relative balance between stress (JNK) and survival (RTK) signaling determines the cellular response to UV-induced DNA damage.

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