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Figure 2

Structural evolution of C-terminal domains in the p53 family

Horng Der Ou, Frank Löhr, Vitali Vogel, Werner Mäntele and Volker Dötsch

  • The EMBO Journal (2007) 26, 3463 - 3473
  • doi:10.1038/sj.emboj.7601764

Published online: 21 June 2007

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Gel filtration curves of the C-terminus of CEP-1 and Dmp53. (A) Gel filtration curve of the C-terminus of CEP-1 and two mutant proteins. The R551L, E552L mutant displays an equilibrium between dimer and tetramer. In the K544M, R551L, E552L triple mutant, this equilibrium is strongly shifted toward the tetramer. (B) Gel filtration experiments with the C-terminus of Dmp53 and different mutants. Mutants with deletion of strand beta1 (326–385) or helix H2 (315–361), or carrying the point mutation E353K all convert the tetramer into a dimer.

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