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| Subject Categories: Chromatin & Transcription | Immunology |
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| The EMBO Journal
(2007) 26, 3191–3202, doi:10.1038/sj.emboj.7601742 Published online 14 June 2007 |
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| BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses |
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| Cornelia Brunner1, Anca Sindrilaru2, Irute Girkontaite1, 4, Klaus-Dieter Fischer1, Cord Sunderkötter2, 3 and Thomas Wirth1 |
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1 Institute of Physiological Chemistry, University of Ulm, Ulm, Germany 2 Department of Dermatology and Allergology, University of Ulm, Ulm, Germany To whom correspondence should be addressed Thomas Wirth, Department of Physiological Chemistry, Institute of Physiological Chemistry, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany. Tel.: +49 731 502 3270; Fax: +49 731 502 2892; E-mail: thomas.wirth@uni-ulm.de 3 Present address: Department of Dermatology and Venerology, University of Münster, Germany 4 Present address: Institute of Immunology, University of Vilnius, Lithuania Received 16 November 2006; Accepted 11 May 2007; Published online 14 June 2007. |
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| Abstract |
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BOB.1/OBF.1 is a transcriptional coactivator essential at several stages of B-cell development. In T cells, BOB.1/OBF.1 expression is inducible by co-stimulation. However, a defined role of BOB.1/OBF.1 for T-cell function had not been discovered so far. Here, we show that BOB.1/OBF.1 is critical for T helper cell function. BOB.1/OBF.1-/- mice showed imbalanced immune responses, resulting in increased susceptibility to Leishmania major infection. Functional analyses revealed specific defects in TH1 and TH2 cells. Whereas expression levels of TH1 cytokines were reduced, the secretion of TH2 cytokines was increased. BOB.1/OBF.1 directly contributes to the IFN and IL2 promoter activities. In contrast, increased TH2 cytokine production is controlled indirectly, probably via the transcription factor PU.1, the expression of which is regulated by BOB.1/OBF.1. Thus, BOB.1/OBF.1 regulates the balance of TH1 versus TH2 mediated immunity. |
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| Keywords: BOB.1/OBF.1, IFN, Leishmania major, PU.1, T helper cells |
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