Article
- The EMBO Journal (2007) 26, 3191 - 3202
- doi:10.1038/sj.emboj.7601742
Published online: 14 June 2007
Subject Categories:
BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses
Cornelia Brunner1, Anca Sindrilaru2, Irute Girkontaite1,b, Klaus-Dieter Fischer1, Cord Sunderkötter2,a and Thomas Wirth1
- Institute of Physiological Chemistry, University of Ulm, Ulm, Germany
- Department of Dermatology and Allergology, University of Ulm, Ulm, Germany
Correspondence to:
Thomas Wirth, Department of Physiological Chemistry, Institute of Physiological Chemistry, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany. Tel.: +49 731 502 3270; Fax: +49 731 502 2892; E-mail: thomas.wirth@uni-ulm.de
aPresent address: Department of Dermatology and Venerology, University of Münster, Germany
bPresent address: Institute of Immunology, University of Vilnius, Lithuania
Received 16 November 2006; Accepted 11 May 2007
Abstract
BOB.1/OBF.1 is a transcriptional coactivator essential at several stages of B-cell development. In T cells, BOB.1/OBF.1 expression is inducible by co-stimulation. However, a defined role of BOB.1/OBF.1 for T-cell function had not been discovered so far. Here, we show that BOB.1/OBF.1 is critical for T helper cell function. BOB.1/OBF.1-/- mice showed imbalanced immune responses, resulting in increased susceptibility to Leishmania major infection. Functional analyses revealed specific defects in TH1 and TH2 cells. Whereas expression levels of TH1 cytokines were reduced, the secretion of TH2 cytokines was increased. BOB.1/OBF.1 directly contributes to the IFN
and IL2 promoter activities. In contrast, increased TH2 cytokine production is controlled indirectly, probably via the transcription factor PU.1, the expression of which is regulated by BOB.1/OBF.1. Thus, BOB.1/OBF.1 regulates the balance of TH1 versus TH2 mediated immunity.
Keywords:
- BOB.1/OBF.1,
- IFN,
- Leishmania major,
- PU.1,
- T helper cells
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
REVIEWS
NFAT proteins: key regulators of T-cell development and function
Nature Reviews Immunology Review (01 Jun 2005)
NEWS AND VIEWS
Regulation of T H I differentiation ? controlling the controllers
Nature Immunology News and Views (01 Jun 2002)
RESEARCH
Deletion of a conserved Il4 silencer impairs T helper type 1?mediated immunity
Nature Immunology Article (01 Dec 2004)
T-bet is a STAT1-induced regulator of IL-12R expression in na???ve CD4 + T cells
Nature Immunology Article (01 Jun 2002)
Nature Immunology Article (01 Nov 2005)
