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Figure 2

GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover

Scott R Frank, Molly R Adelstein and Steen H Hansen

  • The EMBO Journal (2006) 25, 1848 - 1859
  • doi:10.1038/sj.emboj.7601092

Published online: 20 April 2006

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GIT2 knockdown induces FA turnover in HeLa cells. (A–L) Control, GIT1, GIT2, and GIT1&2 knockdown cells were stained for paxillin (green) and F-actin (red). GIT2-kd and GIT1&2-kd cells show a dramatic reduction in FA size that is associated with the redistribution of paxillin to peripheral focal FCs (enlargement J', K', L'). (M, N) Control and GIT2 knockdown cells were stained for vinculin. The enlarged image (N') shows that vinculin also redistributes to peripheral FCs upon GIT2 knockdown. Scale bar: 20 muM.

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