|
 |
|
|
| Subject Categories: Chromatin & Transcription | Genome Stability & Dynamics |
|
| The EMBO Journal
(2006) 25, 1915–1923, doi:10.1038/sj.emboj.7601071 Published online 6 April 2006 |
|
| Cockayne syndrome B protein regulates the transcriptional program after UV irradiation |
|
|
| Luca Proietti-De-Santis, Pascal Drané and Jean-Marc Egly |
|
|
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM, Illkirch Cedex, CU Strasbourg, France To whom correspondence should be addressed Jean-Marc Egly, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM, BP 163, Illkirch Cedex, CU Strasbourg 67404, France. Tel.: +33 388 65 34 47; Fax: +33 388 65 32 01; E-mail: egly@igbmc.u-strasbg.fr Received 3 February 2006; Accepted 7 March 2006; Published online 6 April 2006. |
|
|
|
| Abstract |
|
| The phenotype of the human genetic disorder Cockayne syndrome (CS) is not only due to DNA repair defect but also (and perhaps essentially) to a severe transcription initiation defect. After UV irradiation, even undamaged genes are not transcribed in CSB cells. Indeed, neither RNA pol II nor the associated basal transcription factors are recruited to the promoters of the housekeeping genes, around of which histone H4 acetylation is also deficient. Transfection of CSB restores the recruitment process of RNA pol II. On the contrary, the p53-responsive genes do not require CSB and are transcribed in both wild-type and CSB cells upon DNA damage. Altogether, our data highlight the pivotal role of CSB in initiating the transcriptional program of certain genes after UV irradiation, and also may explain some of the complex traits of CS patients. |
|
| Keywords: CSB, p53, RNA polymerase II, transcription initiation |
|
|
|
Top of page MORE ARTICLES LIKE THISThese links to content published by NPG are automatically generated NEWS AND VIEWSNature Genetics News and Views (01 Nov 2000) Nature News and Views (20 Aug 1992) RESEARCHCircumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer Nature Immunology Article (01 Oct 2001) Initiation of DNA repair mediated by a stalled RNA polymerase IIO The EMBO Journal Article (25 Jan 2006) |
|
|
| |
| |
| |
 | Email link to a friend |
| |
 | Download PDF |
| |
 | Full text |
| |
| |
| |
 | Next article |
| |
 | Previous article |
| |
 | Table of contents |
| |
| |
 | Rights and permissions |
| |
 | Reprints |
| |
| |
| |
 Register for table of contents by email | |
| |
| |
| |
