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| Subject Categories: Signal Transduction | Cell Cycle |
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| The EMBO Journal
(2006) 25, 655–661, doi:10.1038/sj.emboj.7600967 Published online 26 January 2006 |
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| Phosphoinositide 3-kinase controls early and late events in mammalian cell division |
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| Zaira García, Amit Kumar, Miriam Marqués, Isabel Cortés and Ana C Carrera |
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Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain To whom correspondence should be addressed Ana C Carrera, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Darwin 3, Campus de Cantoblanco, Madrid E-28049, Spain. Tel.: +34 91 585 4846; Fax: +34 91 372 0493; E-mail: acarrera@cnb.uam.es Received 25 October 2005; Accepted 23 December 2005; Published online 26 January 2006. |
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| Abstract |
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| Phosphoinositide 3-kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin-dependent kinases. Fine-tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer. |
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| Keywords: cancer, cell cycle, p85 regulatory subunit, phosphatidylinositol 3-kinase |
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