New EMBO Members Review
- The EMBO Journal (2006) 25, 655 - 661
- doi:10.1038/sj.emboj.7600967
Published online: 26 January 2006
Subject Categories:
Phosphoinositide 3-kinase controls early and late events in mammalian cell division
Zaira García, Amit Kumar, Miriam Marqués, Isabel Cortés and Ana C Carrera
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain
Correspondence to:
Ana C Carrera, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Darwin 3, Campus de Cantoblanco, Madrid E-28049, Spain. Tel.: +34 91 585 4846; Fax: +34 91 372 0493; E-mail: acarrera@cnb.uam.es
Received 25 October 2005; Accepted 23 December 2005
Abstract
Phosphoinositide 3-kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin-dependent kinases. Fine-tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer.
Keywords:
- cancer,
- cell cycle,
- p85 regulatory subunit,
- phosphatidylinositol 3-kinase
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