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| Subject Categories: Proteins | Plant Biology |
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| The EMBO Journal
(2006) 25, 5907–5918, doi:10.1038/sj.emboj.7601472 Published online 30 November 2006 |
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| ATAB2 is a novel factor in the signalling pathway of light-controlled synthesis of photosystem proteins |
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Frédy Barneche1, 2, Veronika Winter2, Michèle Crèvec ur and Jean-David Rochaix
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Departments of Molecular Biology and Plant Biology, University of Geneva, Geneva, Switzerland To whom correspondence should be addressed Jean-David Rochaix, Departments of Molecular Biology and Plant Biology, University of Geneva, 30, Quai Ernest Ansermet, 1211 Geneva 4, Switzerland. Tel.: +41 22 379 6187; Fax: +41 22 379 6868; E-mail: Jean-David.Rochaix@molbio.unige.ch 1 Present address: Cell Signalling Laboratory, Stazione Zoologica 'A Dohrn', Villa Comunale, 80121, Naples, Italy 2 These authors contributed equally to this work Received 2 June 2006; Accepted 6 November 2006; Published online 30 November 2006. |
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| Abstract |
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| Plastid translational control depends to a large extent on the light conditions, and is presumably mediated by nucleus-encoded proteins acting on organelle gene expression. However, the molecular mechanisms of light signalling involved in translation are still poorly understood. We investigated the role of the Arabidopsis ortholog of Tab2, a nuclear gene specifically required for translation of the PsaB photosystem I subunit in the unicellular alga Chlamydomonas. Inactivation of ATAB2 strongly affects Arabidopsis development and thylakoid membrane biogenesis and leads to an albino phenotype. Moreover the rate of synthesis of the photosystem reaction center subunits is decreased and the association of their mRNAs with polysomes is affected. ATAB2 is a chloroplast A/U-rich RNA-binding protein that presumably functions as an activator of translation with at least two targets, one for each photosystem. During early seedling development, ATAB2 blue-light induction is lowered in photoreceptor mutants, notably in those lacking cryptochromes. Considering its role in protein synthesis and its photoreceptor-mediated expression, ATAB2 represents a novel factor in the signalling pathway of light-controlled translation of photosystem proteins during early plant development. |
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| Keywords: Arabidopsis, chloroplast, cryptochrome, photosystem, RNA-binding protein |
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Top of page MORE ARTICLES LIKE THISThese links to content published by NPG are automatically generated RESEARCHThe EMBO Journal Article The EMBO Journal Article (15 Sep 1998) Tab2 is a novel conserved RNA binding protein required for translation of the chloroplast psaB mRNA The EMBO Journal Article (01 Dec 2003) Tab2 is a novel conserved RNA binding protein required for translation of the chloroplast psaB mRNA The EMBO Journal Article (01 Dec 2003) |
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