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| Subject Categories: RNA | Development |
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| The EMBO Journal
(2006) 25, 4263–4270, doi:10.1038/sj.emboj.7601304 Published online 31 August 2006 |
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| Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs |
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| Kyung Ho Lee1, Seongju Lee1, Byunghyuk Kim1, Sunghoe Chang2, Soo Woong Kim3, Jae-Seung Paick3 and Kunsoo Rhee1 |
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1 Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul, Korea 2 Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea 3 Department of Urology, College of Medicine, Seoul National University, Seoul, Korea To whom correspondence should be addressed Kunsoo Rhee, Department of Biological Sciences, Seoul National University, San 56-1 Kwanak-Gu, Seoul 151-742, Korea. Tel.: +82 2 880 5751; Fax: +82 2 873 5751; E-mail: rheek@snu.ac.kr Received 2 February 2006; Accepted 1 August 2006; Published online 31 August 2006. |
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| Abstract |
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| Male germ cell development includes mitotic and meiotic cell divisions that are followed by dramatic morphological changes resulting in the production of spermatozoa. Genetic evidence has indicated that the DAZ family genes are critical for successful male germ cell development in diverse animals as well as humans. In the present study, we investigated the cellular functions of Dazl in the mouse male germ cells. We identified a specific interaction of Dazl with the dynein light chain, a component of the dynein–dynactin motor complex. The subcellular distribution of Dazl was microtubule-dependent and a selected number of Dazl-bound mRNAs could accumulate in the perinuclear area. Based on these results, we propose that Dazl may play a role in transport of specific mRNAs via dynein motor complex. The Dazl-bound mRNAs may be stored at specific sites and would be available for future developmental processes. Our study revealed the presence of an active mRNA transport system in mouse male germ cells. |
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| Keywords: Dazl, dynein, dynein light chain, male infertility, mRNA transport |
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Top of page MORE ARTICLES LIKE THISThese links to content published by NPG are automatically generated RESEARCHDazl can bind to dynein motor complex and may play a role in transport of specific mRNAs The EMBO Journal Article The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells The EMBO Journal Article (20 Jul 2005) Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule Nature Cell Biology Article (01 Jul 1999) The EMBO Journal Article (01 Aug 2001) |
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