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The EMBO Journal (2006) 25, 3774–3783, doi:10.1038/sj.emboj.7601263

Published online 3 August 2006
Figure 2
MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
Deepak Raina, Rehan Ahmad, Shailendra Kumar, Jian Ren, Kiyotsugu Yoshida, Surender Kharbanda and Donald Kufe
Figure 2
Figure 2
 c-Abl is targeted to the nucleus by silencing MUC1 in ZR-75-1 cells. (A) Lysates from ZR-75-1/vector and ZR-75-1/MUC1siRNA cells were subjected to immunoblotting with anti-MUC1-N, anti-MUC1-C, anti-c-Abl or anti-beta-actin. (B and C) ZR-75-1/vector and ZR-75-1/MUC1siRNA cells were treated with CDDP for 2 and 4 h. Nuclear (B) and cytosolic (C) fractions were subjected to immunoblot analysis with the indicated antibodies.
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