Table of Contents
Volume 24, Number 3
09 February 2005
pp 439-655
Crystal structure of a complex between the human heterodimeric SUMO E1 activating enzyme (Sae1/Sae2), SUMO-1, and Mg-ATP. SUMO (yellow) is a member of the ubiquitin and ubiquitin-like protein family and is activated by a dedicated E1 enzyme (blue, pink, and red) in an ATP-dependent process. The SUMO E1 then recruits its cognate SUMO E2 via the Ubl domain (red) to facilitate SUMO transfer between E1 and E2. Once transferred to E2, SUMO can be conjugated to protein targets directly, or through complexes mediated by E3 ligases. For further details, please see the article by Lois & Lima on pages 439-451 of this issue of The EMBO Journal.
Articles
Top of pageStructures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1 FREE
The EMBO Journal (2005), 24, - 439 - 451, doi:10.1038/sj.emboj.7600552
- Abstract - Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
- Full text
- PDF (573 KB) - Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
- Supplementary information
Published online: 20 January 2005
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The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles FREE
The EMBO Journal (2005), 24, - 452 - 463, doi:10.1038/sj.emboj.7600554
- Abstract - The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles
- Full text
- PDF (716 KB) - The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles
Published online: 20 January 2005
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Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases FREE
The EMBO Journal (2005), 24, - 464 - 472, doi:10.1038/sj.emboj.7600537
- Abstract - Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases
- Full text
- PDF (283 KB) - Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases
Published online: 23 December 2004
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Interplay between components of a novel LIM kinase–slingshot phosphatase complex regulates cofilin FREE
The EMBO Journal (2005), 24, - 473 - 486, doi:10.1038/sj.emboj.7600543
- Abstract - Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin
- Full text
- PDF (476 KB) - Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin
- Supplementary information
Published online: 20 January 2005
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Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism FREE
The EMBO Journal (2005), 24, - 487 - 498, doi:10.1038/sj.emboj.7600558
- Abstract - Src42 binding activity regulates : Drosophila: RAF by a novel CNK-dependent derepression mechanism
- Full text
- PDF (493 KB) - Src42 binding activity regulates : Drosophila: RAF by a novel CNK-dependent derepression mechanism
- Supplementary information
Published online: 20 January 2005
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Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR FREE
The EMBO Journal (2005), 24, - 499 - 509, doi:10.1038/sj.emboj.7600557
- Abstract - Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR
- Full text
- PDF (212 KB) - Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR
Published online: 20 January 2005
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Positive and negative regulation of EAAT2 by NF-
B: a role for N-myc in TNF
-controlled repression
FREE The EMBO Journal (2005), 24, - 510 - 520, doi:10.1038/sj.emboj.7600555
- Abstract - Positive and negative regulation of EAAT2 by NF-[kappa]B: a role for N-myc in TNF[alpha]-controlled repression
- Full text
- PDF (250 KB) - Positive and negative regulation of EAAT2 by NF-[kappa]B: a role for N-myc in TNF[alpha]-controlled repression
- Supplementary information
Published online: 20 January 2005
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Inducible dissociation of SCFMet30 ubiquitin ligase mediates a rapid transcriptional response to cadmium FREE
The EMBO Journal (2005), 24, - 521 - 532, doi:10.1038/sj.emboj.7600556
- Abstract - Inducible dissociation of SCF: Met30: ubiquitin ligase mediates a rapid transcriptional response to cadmium
- Full text
- PDF (598 KB) - Inducible dissociation of SCF: Met30: ubiquitin ligase mediates a rapid transcriptional response to cadmium
Published online: 20 January 2005
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Central role of Ifh1p–Fhl1p interaction in the synthesis of yeast ribosomal proteins FREE
The EMBO Journal (2005), 24, - 533 - 542, doi:10.1038/sj.emboj.7600553
- Abstract - Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins
- Full text
- PDF (314 KB) - Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins
- Supplementary information
Published online: 03 February 2005
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The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor FREE
The EMBO Journal (2005), 24, - 543 - 553, doi:10.1038/sj.emboj.7600550
- Abstract - The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor
- Full text
- PDF (296 KB) - The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor
- Supplementary information
Published online: 20 January 2005
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In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents FREE
The EMBO Journal (2005), 24, - 554 - 566, doi:10.1038/sj.emboj.7600546
- Abstract - In vivo: haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents
- Full text
- PDF (925 KB) - In vivo: haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents
Published online: 20 January 2005
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Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p
The EMBO Journal (2005), 24, - 567 - 579, doi:10.1038/sj.emboj.7600547
- Abstract - Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p
- Full text
- PDF (692 KB) - Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p
- Supplementary information
Published online: 20 January 2005
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Functional link between ribosome formation and biogenesis of iron–sulfur proteins
The EMBO Journal (2005), 24, - 580 - 588, doi:10.1038/sj.emboj.7600540
- Abstract - Functional link between ribosome formation and biogenesis of iron-sulfur proteins
- Full text
- PDF (437 KB) - Functional link between ribosome formation and biogenesis of iron-sulfur proteins
- Supplementary information
Published online: 20 January 2005
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Biogenesis of cytosolic ribosomes requires the essential iron–sulphur protein Rli1p and mitochondria
The EMBO Journal (2005), 24, - 589 - 598, doi:10.1038/sj.emboj.7600541
- Abstract - Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria
- Full text
- PDF (286 KB) - Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria
Published online: 20 January 2005
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SCFPof1-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast FREE
The EMBO Journal (2005), 24, - 599 - 610, doi:10.1038/sj.emboj.7600536
- Abstract - SCF: Pof1: -ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast
- Full text
- PDF (331 KB) - SCF: Pof1: -ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast
- Supplementary information
Published online: 20 January 2005
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A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis FREE
The EMBO Journal (2005), 24, - 611 - 622, doi:10.1038/sj.emboj.7600549
- Abstract - A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis
- Full text
- PDF (747 KB) - A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis
Published online: 20 January 2005
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The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth FREE
The EMBO Journal (2005), 24, - 623 - 634, doi:10.1038/sj.emboj.7600523
- Abstract - The : Drosophila: mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth
- Full text
- PDF (725 KB) - The : Drosophila: mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth
- Supplementary information
Published online: 03 February 2005
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Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation FREE
The EMBO Journal (2005), 24, - 635 - 644, doi:10.1038/sj.emboj.7600538
- Abstract - Elf5: is essential for early embryogenesis and mammary gland development during pregnancy and lactation
- Full text
- PDF (630 KB) - Elf5: is essential for early embryogenesis and mammary gland development during pregnancy and lactation
Published online: 13 January 2005
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XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs FREE
The EMBO Journal (2005), 24, - 645 - 655, doi:10.1038/sj.emboj.7600544
- Abstract - XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
- Full text
- PDF (296 KB) - XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
- Supplementary information
Published online: 13 January 2005
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