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The EMBO Journal (2005) 24, 2379–2390, doi:10.1038/sj.emboj.7600711 Published online 9 June 2005 Figure 8 Altered nucleosome occupancy and histone H3K4 methylation in response to 'transcriptional stress' Lian Zhang, Stephanie Schroeder, Nova Fong and David L Bentley

Figure 8 Model for chromatin reconfiguration in response to 'transcriptional stress'. Impaired pol II transcription causes preferential recruitment of nucleosomes to promoter distal regions of the transcription unit, which can be accompanied by increased H3K4 trimethylation indicated with stars. This chromatin reconfiguration could be mediated by Chd1 and yet unidentified assembly factor(s). Inhibition of transcription by 6-AU also caused net loss of H3 and H3K4 trimethylation at the 5' end.

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