Article
- The EMBO Journal (2004) 23, 1336 - 1347
- doi:10.1038/sj.emboj.7600134
Published online: 4 March 2004
Subject Category:
Combinatorial gene control involving E2F and E Box family members
Paloma H Giangrande, Wencheng Zhu, Rachel E Rempel, Nina Laakso and Joseph R Nevins
- Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA
Correspondence to:
Joseph R Nevins, Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, CARL Building, Room 268, Durham, NC 27710, USA. Tel.: +1 919 684 2746; Fax: +1 919 681 8973; E-mail: J.Nevins@duke.edu
Received 20 August 2003; Accepted 29 January 2004
Abstract
Various studies point to the potential role of combinatorial action of transcription factors as a mechanism to achieve the complexity of eukaryotic gene control with a finite number of regulatory proteins. Our previous work has focused on interactions involving the E2F family of transcription factors as an example of combinatorial gene control, leading to the identification of TFE3 and YY1 as transcription partners for several E2F proteins. We now show that additional E2F target genes share a common promoter architecture and are also regulated by the combined action of TFE3 and E2F3. In contrast, the thymidine kinase (TK-1) promoter is also regulated by E2F3 but independent of TFE3. Other promoters exhibit distinct specificity in the interaction with E2F proteins that includes a role for E2F1 but not E2F3, examples where both E2F1 and E2F3 are seen to interact, and promoters that are regulated by TFE3 but independent of an E2F. We propose that these examples of combinatorial interactions involving E2F proteins provide a basis for the specificity of transcription control in the Rb/E2F pathway.
Keywords:
- combinatorial transcription control,
- E2F,
- TFE3,
- USF1
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