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| Subject Categories: Immunology |
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| The EMBO Journal
(2004) 23, 1325–1335, doi:10.1038/sj.emboj.7600133 Published online 18 March 2004 |
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| JunD regulates lymphocyte proliferation and T helper cell cytokine expression |
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| Arabella Meixner1, Florian Karreth, Lukas Kenner and Erwin F Wagner |
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Research Institute of Molecular Pathology (IMP), Vienna, Austria To whom correspondence should be addressed Erwin F Wagner, Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria. Tel.: +43 1 797 30888; Fax: +43 1 798 9390; E-mail: wagner@imp.univie.ac.at 1 Present address: Institute of Molecular Biotechnology (IMBA), Dr Bohr-Gasse 3-5, A-1030 Vienna, Austria Received 17 November 2003; Accepted 29 January 2004; Published online 18 March 2004. |
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| Abstract |
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Transgenic mice broadly expressing JunD (Ubi-junDm) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes. JunD overexpression in lymphocytes does not protect from numerous apoptotic insults; however, transgenic T cells proliferate poorly and exhibit impaired activation due to reduced levels of IL-4, CD25 and CD69. Consistently, in the absence of JunD (junD-/-) T cells hyperproliferate following mitogen induction. Moreover, transgenic T helper (Th) 2 cells have decreased IL-4 and IL-10 expression, whereas junD-/- Th2 cells secrete higher amounts of both Th2 cytokines. Th1-polarized junD-/- CD4+ T cells display enhanced IFN- cytokine production associated with upregulated T-bet expression and downregulated expression of suppressor of cytokine signaling-1. These novel findings demonstrate a regulatory role of JunD in T lymphocyte proliferation and Th cell differentiation. |
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| Keywords: IL-4, IL-10, JunD, lymphocytes, SOCS1, T-bet, Th cells |
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Top of page MORE ARTICLES LIKE THISThese links to content published by NPG are automatically generated RESEARCHTh2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB The EMBO Journal Article (01 Dec 2002) JunB is a gatekeeper for B-lymphoid leukemia Oncogene Original Article Biphasic Regulation of AP-1 Subunits during Human Epidermal Wound Healing Journal of Investigative Dermatology Original Article |
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