Table of Contents
Volume 23, Number 4
25 February 2004
pp 681-988
"Secretome City" - Illustration based on a 2-D DIGE image
Fluorescence 2-D difference gel electrophoresis (2-D DIGE) with two different CyDye fluors can be used for direct differential protein expression analysis. Here, the cellular proteome was compared to the "secretome", both derived from the same colon cancer cells in vitro. Green spots represent proteins exlusively present in the cell lysate and red spots show proteins highly enriched in the secretome. The image was produced by Martin W. Volmer, a PhD student in the group of Irmgard Schwarte-Waldhoff at the University of Bochum, Germany, and illustrates part of a project investigating the role of the tumor suppressor gene Smad4 in colorectal carcinogenesis and its impact on the tumor cells' microenvironment. Further information can be found in Volmer et al (2004), Proteomics, in press.
The original image is printed with kind permission of Proteomics (Wiley-VCH).
Articles
Top of pageConstitutive versus regulated SNARE assembly: a structural basis FREE
The EMBO Journal (2004), 23, - 681 - 689, doi:10.1038/sj.emboj.7600083
- Abstract - Constitutive versus regulated SNARE assembly: a structural basis
- Full text
- PDF (324 KB) - Constitutive versus regulated SNARE assembly: a structural basis
- Supplementary information
Published online: 05 February 2004
Subject Categories:
Molecular architecture of photosynthetic membranes in Rhodobacter sphaeroides: the role of PufX FREE
The EMBO Journal (2004), 23, - 690 - 700, doi:10.1038/sj.emboj.7600092
- Abstract - Molecular architecture of photosynthetic membranes in : Rhodobacter sphaeroides: : the role of PufX
- Full text
- PDF (581 KB) - Molecular architecture of photosynthetic membranes in : Rhodobacter sphaeroides: : the role of PufX
- Supplementary information
Published online: 05 February 2004
Subject Categories:
The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel
-roll
FREE The EMBO Journal (2004), 23, - 701 - 711, doi:10.1038/sj.emboj.7600100
- Abstract - The : Yersinia: adhesin YadA collagen-binding domain structure is a novel left-handed parallel [beta]-roll
- Full text
- PDF (417 KB) - The : Yersinia: adhesin YadA collagen-binding domain structure is a novel left-handed parallel [beta]-roll
- Supplementary information
Published online: 05 February 2004
Subject Categories:
Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin FREE
The EMBO Journal (2004), 23, - 712 - 718, doi:10.1038/sj.emboj.7600093
- Abstract - Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca: 2+: /calmodulin
- Full text
- PDF (257 KB) - Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca: 2+: /calmodulin
Published online: 12 February 2004
Subject Categories:
Mapping key functional sites within yeast TFIID FREE
The EMBO Journal (2004), 23, - 719 - 727, doi:10.1038/sj.emboj.7600111
- Abstract - Mapping key functional sites within yeast TFIID
- Full text
- PDF (339 KB) - Mapping key functional sites within yeast TFIID
Published online: 12 February 2004
Subject Categories:
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation FREE
The EMBO Journal (2004), 23, - 728 - 738, doi:10.1038/sj.emboj.7600064
- Abstract - Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation
- Full text
- PDF (718 KB) - Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation
Published online: 12 February 2004
Subject Categories:
The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly FREE
The EMBO Journal (2004), 23, - 739 - 748, doi:10.1038/sj.emboj.7600066
- Abstract - The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly
- Full text
- PDF (396 KB) - The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly
- Supplementary information
Published online: 05 February 2004
Subject Categories:
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation FREE
The EMBO Journal (2004), 23, - 749 - 759, doi:10.1038/sj.emboj.7600084
- Abstract - Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
- Full text
- PDF (476 KB) - Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
- Supplementary information
Published online: 05 February 2004
Subject Categories:
DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner FREE
The EMBO Journal (2004), 23, - 760 - 771, doi:10.1038/sj.emboj.7600095
- Abstract - DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner
- Full text
- PDF (592 KB) - DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner
- Supplementary information
Published online: 05 February 2004
Subject Categories:
A troponin switch that regulates muscle contraction by stretch instead of calcium FREE
Bogos Agianian, Uro
Kr
i
,
Feng Qiu,
Wolfgang A Linke,
Kevin Leonard and Belinda BullardThe EMBO Journal (2004), 23, - 772 - 779, doi:10.1038/sj.emboj.7600097
- Abstract - A troponin switch that regulates muscle contraction by stretch instead of calcium
- Full text
- PDF (291 KB) - A troponin switch that regulates muscle contraction by stretch instead of calcium
Published online: 12 February 2004
Subject Categories:
A differential role for actin during the life cycle of Trypanosoma brucei FREE
The EMBO Journal (2004), 23, - 780 - 789, doi:10.1038/sj.emboj.7600094
- Abstract - A differential role for actin during the life cycle of : Trypanosoma brucei
- Full text
- PDF (402 KB) - A differential role for actin during the life cycle of : Trypanosoma brucei
Published online: 12 February 2004
Subject Categories:
Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription FREE
The EMBO Journal (2004), 23, - 790 - 799, doi:10.1038/sj.emboj.7600073
- Abstract - Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
- Full text
- PDF (376 KB) - Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
Published online: 12 February 2004
Subject Categories:
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis FREE
The EMBO Journal (2004), 23, - 800 - 810, doi:10.1038/sj.emboj.7600075
- Abstract - Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis
- Full text
- PDF (291 KB) - Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis
- Supplementary information
Published online: 12 February 2004
Subject Categories:
A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen FREE
The EMBO Journal (2004), 23, - 811 - 822, doi:10.1038/sj.emboj.7600112
- Abstract - A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen
- Full text
- PDF (487 KB) - A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen
- Supplementary information
Published online: 12 February 2004
Subject Categories:
DCX, a new mediator of the JNK pathway FREE
The EMBO Journal (2004), 23, - 823 - 832, doi:10.1038/sj.emboj.7600079
- Abstract - DCX, a new mediator of the JNK pathway
- Full text
- PDF (497 KB) - DCX, a new mediator of the JNK pathway
- Supplementary information
Published online: 05 February 2004
Subject Categories:
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 FREE
The EMBO Journal (2004), 23, - 833 - 843, doi:10.1038/sj.emboj.7600110
- Abstract - LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
- Full text
- PDF (586 KB) - LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
- Supplementary information
Published online: 19 February 2004
Subject Categories:
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus FREE
The EMBO Journal (2004), 23, - 844 - 856, doi:10.1038/sj.emboj.7600101
- Abstract - Transcriptional regulation of BMP4 synexpression in transgenic : Xenopus
- Full text
- PDF (893 KB) - Transcriptional regulation of BMP4 synexpression in transgenic : Xenopus
- Supplementary information
Published online: 12 February 2004
Subject Categories:
Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module FREE
The EMBO Journal (2004), 23, - 857 - 868, doi:10.1038/sj.emboj.7600108
- Abstract - Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module
- Full text
- PDF (434 KB) - Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module
- Supplementary information
Published online: 12 February 2004
Subject Categories:
Asynchronous basepair openings in transcription initiation: CRP enhances the rate-limiting step FREE
The EMBO Journal (2004), 23, - 869 - 875, doi:10.1038/sj.emboj.7600098
- Abstract - Asynchronous basepair openings in transcription initiation: CRP enhances the rate-limiting step
- Full text
- PDF (222 KB) - Asynchronous basepair openings in transcription initiation: CRP enhances the rate-limiting step
Published online: 12 February 2004
Subject Categories:
Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses FREE
The EMBO Journal (2004), 23, - 876 - 884, doi:10.1038/sj.emboj.7600096
- Abstract - Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses
- Full text
- PDF (270 KB) - Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses
Published online: 19 February 2004
Subject Categories:
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart
The EMBO Journal (2004), 23, - 885 - 896, doi:10.1038/sj.emboj.7600054
- Abstract - Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart
- Full text
- PDF (432 KB) - Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart
Published online: 12 February 2004
Subject Categories:
DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC–DNA binding FREE
The EMBO Journal (2004), 23, - 897 - 907, doi:10.1038/sj.emboj.7600077
- Abstract - DNA topology, not DNA sequence, is a critical determinant for : Drosophila: ORC-DNA binding
- Full text
- PDF (419 KB) - DNA topology, not DNA sequence, is a critical determinant for : Drosophila: ORC-DNA binding
- Supplementary information
Published online: 05 February 2004
Subject Categories:
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1 FREE
The EMBO Journal (2004), 23, - 908 - 918, doi:10.1038/sj.emboj.7600105
- Abstract - Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
- Full text
- PDF (344 KB) - Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
- Supplementary information
Published online: 05 February 2004
Subject Categories:
Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation
The EMBO Journal (2004), 23, - 919 - 929, doi:10.1038/sj.emboj.7600103
- Abstract - Fission yeast Clp1p phosphatase affects G: 2: /M transition and mitotic exit through Cdc25p inactivation
- Full text
- PDF (371 KB) - Fission yeast Clp1p phosphatase affects G: 2: /M transition and mitotic exit through Cdc25p inactivation
Published online: 12 February 2004
Subject Categories:
Formation, maintenance and consequences of the imprint at the mating-type locus in fission yeast FREE
The EMBO Journal (2004), 23, - 930 - 938, doi:10.1038/sj.emboj.7600099
- Abstract - Formation, maintenance and consequences of the imprint at the mating-type locus in fission yeast
- Full text
- PDF (380 KB) - Formation, maintenance and consequences of the imprint at the mating-type locus in fission yeast
Published online: 12 February 2004
Subject Category:
In vivo assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repair FREE
The EMBO Journal (2004), 23, - 939 - 949, doi:10.1038/sj.emboj.7600091
- Abstract - In vivo: assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repair
- Full text
- PDF (280 KB) - In vivo: assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repair
- Supplementary information
Published online: 05 February 2004
Subject Category:
ATF6 modulates SREBP2-mediated lipogenesis FREE
The EMBO Journal (2004), 23, - 950 - 958, doi:10.1038/sj.emboj.7600106
- Abstract - ATF6 modulates SREBP2-mediated lipogenesis
- Full text
- PDF (407 KB) - ATF6 modulates SREBP2-mediated lipogenesis
Published online: 05 February 2004
Subject Categories:
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease FREE
The EMBO Journal (2004), 23, - 959 - 968, doi:10.1038/sj.emboj.7600049
- Abstract - An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease
- Full text
- PDF (353 KB) - An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease
- Supplementary information
Published online: 05 February 2004
Subject Categories:
Runx3 regulates mouse TGF-
-mediated dendritic cell function and its absence results in airway inflammation
FREE The EMBO Journal (2004), 23, - 969 - 979, doi:10.1038/sj.emboj.7600085
- Abstract - Runx3 regulates mouse TGF-[beta]-mediated dendritic cell function and its absence results in airway inflammation
- Full text
- PDF (625 KB) - Runx3 regulates mouse TGF-[beta]-mediated dendritic cell function and its absence results in airway inflammation
- Supplementary information
Published online: 05 February 2004
Subject Categories:
An extracellular aspartic protease functions in Arabidopsis disease resistance signaling
The EMBO Journal (2004), 23, - 980 - 988, doi:10.1038/sj.emboj.7600086
- Abstract - An extracellular aspartic protease functions in : Arabidopsis: disease resistance signaling
- Full text
- PDF (443 KB) - An extracellular aspartic protease functions in : Arabidopsis: disease resistance signaling
Published online: 05 February 2004
Subject Categories:
